Category: Plate

The masking effect of extracellular DNA and robustness of intracellular DNA in anaerobic digester NGS studies

The masking effect of extracellular DNA and robustness of intracellular DNA in anaerobic digester NGS studies

Mostly, NGS-based microbiome research are carried out on the whole DNA (totDNA) pool that, nevertheless, consists of extracellular- (exDNA) and intracellular (iDNA) DNA fractions. By investigating the microbiomes of various anaerobic digesters over time, we discovered that totDNA urged decrease species richness contemplating all and/or solely frequent species and yielded fewer distinctive reads as in comparison with iDNA. Moreover, exDNA-derived sequences had been extra just like these from totDNA than from iDNA and at last, iDNA confirmed the perfect efficiency of monitoring temporal adjustments in microbial communities. We postulate that considerable sequences current throughout the exDNA fraction are masking the general outcomes of totDNA and supply proof that exDNA has the potential to qualitatively bias microbiome research no less than within the anaerobic digester surroundings because it incorporates details about cells that had been lysed hours or days in the past.

iDNA, nevertheless, was discovered extra acceptable to realize dependable genetic details about probably alive in addition to uncommon microbes throughout the goal habitat. We in contrast the diagnostic efficiency, turn-around time, and price of those assays. Carbapenemase genes had been outlined utilizing the Carba NP check, modified Carbapenem Inactivation Strategies (mCIM), multiplex PCR, and whole-genome sequencing. We included medical Enterobacterales isolates (n = 36) and nonfermenting gram-negative bacilli isolates (n = 17) collected from 16 acute-care hospitals within the Kinki area of Japan.

Subsequent-generation sequencing (NGS) is broadly used for genome-wide identification and quantification of DNA parts concerned within the regulation of gene transcription. Research that generate a number of high-throughput NGS datasets require knowledge integration strategies for 2 basic duties: 1) technology of genome-wide knowledge tracks representing an combination of a number of replicates of the identical experiment; and a pair of) mixture of tracks from totally different experimental sorts that present complementary data concerning the situation of genomic options reminiscent of enhancers.

 NGS-Integrator is a Java-based command line utility, facilitating environment friendly integration of a number of genome-wide NGS datasets. NGS-Integrator first transforms all enter knowledge tracks utilizing the complement of the minimal Bayes’ issue so that each one values are expressed within the vary [0,1] representing the chance of a real sign given the background noise. Then, NGS-Integrator calculates the joint chance for each genomic place to create an built-in monitor. We offer examples utilizing actual NGS knowledge generated in our laboratory and from the mouse ENCODE database. To forestall the emergence of ceftriaxone resistance in Russia, NG-MAST genotyping should be supplemented with penA allele evaluation.

 

A Easy and Sturdy Enzymatic Fragmentation Methodology for NGS Library Development

A Easy and Sturdy Enzymatic Fragmentation Methodology for NGS Library Development Bin Li (1), James Anderson (1), Ewa Patrycja Malc (2), Piotr Mieczkowski (2), Lin Pham (1) 1 Tecan Genomics, Redwood Metropolis, CA 2 Excessive Throughput Sequencing Facility, Division of Genetics, College of North Carolina, Chapel Hill, USA Subsequent Technology Sequencing strategies have co-evolved with sequencers to work optimally inside a reasonably slender band of DNA fragment lengths. The Illumina methods require fragmenting DNA to a couple hundred base pairs. Bodily shearing strategies, reminiscent of acoustic shearing and sonication, are the commonest DNA shearing strategies.

Sadly, these strategies are laborious, have elevated threat of pattern cross contamination, are tough to automate and the sheared DNA requires restore for adaptor ligation and utility as a template for DNA polymerases. Earlier efforts at using an enzymatic method have i) required titration of enzyme to DNA ii) demonstrated reduce web site bias iii) resulted in a broad fragment size distribution, iv) OR all the above. Right here we current a easy and strong enzymatic methodology to generate random DNA fragments with suitable fragment ends for adaptor ligation.

Tecan’s DNA enzymatic fragmentation methodology is an easy add and incubate workflow that takes about 30 minutes, doesn’t require optimization throughout a variety of enter quantities, gives constant outcomes with out GC bias and is totally automatable. We present reproducible library development on a Tecan automation workstation with constant fragment measurement distribution, and sequencing outcomes of DNA libraries with excessive complexity and low protection bias. This strong and tunable DNA fragmentation methodology means that you can additional simplify your DNA-Seq NGS library preparation workflow.

The masking effect of extracellular DNA and robustness of intracellular DNA in anaerobic digester NGS studies

Molecular Typing of Neisseria gonorrhoeae Medical Isolates in Russia, 2018-2019: A Hyperlink Between penA Alleles and NG-MAST Varieties

This work aimed to review penA gene polymorphisms in medical isolates of Neisseria gonorrhoeae collected in Russia in 2018-2019 and the contribution of the penA allele kind to susceptibility to β-lactam antibiotics. A complete of 182 isolates had been analyzed. penA allele sorts had been decided by sequencing, and the minimal inhibitory concentrations (MICs) of benzylpenicillin and ceftriaxone had been measured. The affect of genetic elements on MICs was evaluated by regression evaluation. All isolates had been prone to ceftriaxone, and 40.1% of isolates had been prone to penicillin.

Eleven penA allele sorts had been recognized. The mosaic kind XXXIV penA allele and the Gly120Lys substitution in PorB made the best contributions to growing the ceftriaxone MIC; the presence of the blaTEM plasmid, Gly120Asp, Ala121Gly/Asn substitutions in PorB, and the adenine deletion within the promoter area of the mtrR gene induced a rise within the penicillin MIC. Amongst 61 NG-MAST sorts recognized, essentially the most frequent had been sorts 228, 807, 9486, 1993, and 6226. A hyperlink between penA alleles and Neisseria gonorrhoeae multi-antigen sequence typing (NG-MAST) sorts was established. Resistance to 2 teams of β-lactam antibiotics was related to non-identical adjustments in penA alleles.

 

Improved Variant Detection in Clinical Myeloid NGS Testing by Supplementing a Commercial Myeloid NGS Assay with Custom or Extended Data Filtering and Accessory Fragment Analysis

Improved Variant Detection in Clinical Myeloid NGS Testing by Supplementing a Commercial Myeloid NGS Assay with Custom or Extended Data Filtering and Accessory Fragment Analysis

Business myeloid next-generation sequencing (NGS) panels might facilitate uniform era of uncooked information between laboratories. Nevertheless, completely different methods for information filtering and variant annotation might contribute to variations in variant detection and reporting. Right here, we current how customized information filtering or the usage of Oncomine prolonged information filtering enhance detection of clinically related mutations with the Oncomine Myeloid Analysis Assay. The research included all affected person samples (n = 264) analyzed throughout the first-year, single-site, scientific use of the Ion Torrent Oncomine Myeloid Analysis Assay.
In information evaluation, the default evaluation filter was supplemented with our personal information filtering algorithm with a purpose to detect further clinically related mutations. As well as, we developed a delicate supplementary take a look at for the ASXL1 c.1934dupG p.Gly646fs mutation by fragment evaluation. Utilizing our customized filter chain, we discovered 96 completely different reportable variants that weren’t detected by the default filter chain. Twenty-six of those have been labeled as variants of sturdy or potential scientific significance (tier I/tier II variants), and the customized filtering found in any other case undetected tier I/tier II variants in 25 of 132 sufferers with clinically related mutations (19%).
The remaining 70 variants not detected by the default filter chain have been labeled as variants of unknown significance. Amongst these have been a number of distinctive variants with attainable pathogenic potential judged by bioinformatic predictions. The lately launched Oncomine 5.14 prolonged filter algorithm detects most however not the entire tier I/tier II variants that weren’t detected by the default filter. The supplementary fragment evaluation for the ASXL1 c.1934dupG p.Gly646fs confidently detected a variant allele frequency of all the way down to 4.8% (SD 0.83%). The assay additionally detected the ASXL1 c.1900_1922del23 mutation.
Detection of clinically related variants with the Oncomine Myeloid Analysis NGS assay will be considerably improved by supplementing the default filter chain with customized information filtering or the lately launched Oncomine 5.14 prolonged filter algorithm. Our accent fragment evaluation facilitates straightforward testing for frequent ASXL1 mutations which might be poorly or not coated by the NGS assay.

Lowered PCR-generated errors from a hybrid capture-based NGS assay for HLA typing

Subsequent era sequencing (NGS) assays are state-of-the-art for HLA genotyping. To sequence on an Illumina sequencer, the DNA of curiosity should be enriched, fragmented, and bookended with identified oligonucleotide sequences, a course of referred to as library building. Many HLA genotyping assays enrich the goal loci by long-range PCR (LR-PCR), previous to fragmentation. This PCR step has been reported to introduce errors within the DNA to be sequenced, together with inaccurate replication of repeated sequences, and the in vitro recombination of alleles encoded on separate chromosomes.

Another library building technique includes fragmentation of genomic DNA, adopted by hybrid-capture (HC) enrichment of goal HLA loci. This HC-based technique includes PCR, however with far fewer cycles. Consequently, the HC technique had considerably fewer PCR-induced errors, together with extra devoted replication of repeated sequences, and the close to elimination of recombinant sequences. These enhancements possible produce extra correct NGS sequencing information of HLA loci. The Ng-H and Ng’-H contacts vary, actually, between sturdy covalent bonds to weak, non-covalent interactions, and their common variability clearly illustrates the peculiar functionality of the noble gases to bear interactions masking your entire spectrum of the chemical bond.

The construction, stability, and bonding character of fifteen (Ng-H-Ng)+ and (Ng-H-Ng’)+ (Ng, Ng’ = He-Xe) compounds have been explored by theoretical calculations carried out on the coupled cluster stage of idea. The character of the stabilizing interactions was, specifically, assayed utilizing a technique lately proposed by the authors to categorise the chemical bonds involving the noble-gas atoms. The bond distances and dissociation energies of the investigated ions fall in relatively massive intervals, and observe common periodic tendencies, clearly referable to the distinction between the proton affinity (PA) of the varied Ng and Ng’. These variations are properly correlated with the bonding state of affairs of the (Ng-H-Ng)+ and (Ng-H-Ng’)+.

Improved Variant Detection in Clinical Myeloid NGS Testing by Supplementing a Commercial Myeloid NGS Assay with Custom or Extended Data Filtering and Accessory Fragment Analysis

NGS-Based mostly Utility for Routine Non-Invasive Pre-Implantation Genetic Evaluation in IVF

Though non-invasive pre-implantation genetic testing for aneuploidy (NIPGT-A) is probably applicable to evaluate chromosomal ploidy of the embryo, sensible software of it in a routine IVF centre haven’t been began within the absence of a suggestion. Our goal on this research was to offer a complete workflow for a clinically relevant technique for NIPGT-A based mostly on next-generation sequencing (NGS) expertise with the corresponding bioinformatic pipeline. In a retrospective research, we carried out NGS on spent blastocyst tradition media of Day three embryos fertilised with intracytoplasmic sperm injection (ICSI) with high quality rating on morphology evaluation utilizing the clean tradition media as background management.

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Accuris MyView™ Compact UV Transilluminator, 230V

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Hi-UV Max Transilluminator

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Description: Hi-UV Max Transilluminator

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UltraBright UV Transilluminator, 302 nm

QMB-16 1
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WUV-M20, UV Transilluminator, 312nm, 100V

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WUV-M20, UV Transilluminator, 312nm, 220V

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UltraBright UV Transilluminator, 302/365 nm

Q-MLB-16 1
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UV Transilluminator 20 x 20 cm 302nm - EACH

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EUR 1274.4

UV Transilluminator 25 x 30 cm 302nm - EACH

ELE7586 EACH
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UV Transilluminator 21 x 21cm 254nm - EACH

ULT4500 EACH
EUR 1455.3

UV Transilluminator 21 x 21cm 312nm - EACH

ULT4502 EACH
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UV Transilluminator 21 x 21cm 365nm - EACH

ULT4504 EACH
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UV Transilluminator 21 x 26cm 254nm - EACH

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UV Transilluminator 21 x 26cm 312nm - EACH

ULT4512 EACH
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UV Transilluminator 21 x 26cm 365nm - EACH

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UltraBright UV Transilluminator, 302 nm (Large View)

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EUR 1150

UltraBright UV Transilluminator, 302/365 nm (Large View)

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Transilluminator 365nm - EACH

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Transilluminator 302nm - EACH

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Transilluminator 254nm - EACH

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Transilluminator 302nm - EACH

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EUR 1431

UV Transilluminator 21 x 21cm Dual Wave 254/365nm - EACH

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UV Transilluminator 21 x 21cm Dual Wave 254/312nm - EACH

ULT4508 EACH
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UV Transilluminator 21 x 26cm Dual Wave 254/365nm - EACH

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Transilluminator 230v 50Hz MW - EACH

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Blue Light Transilluminator - EACH

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EZ-Viewer LED Transilluminator

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UltraBright LED Transilluminator, 470 nm

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SmartBlue™ Transilluminator, 230V input

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SmartBlue™ Mini Transilluminator

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microDOC System with UV Transilluminator UVTS365 21x21cm 365nm - EACH

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Transilluminator 20x20cm 302/365 - EACH

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Transilluminator 25x30cm 302/365 - EACH

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SmartBlue™ Mini Transilluminator, 230V input

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SmartDoc band pass filter, 590nm, for imaging EtBr on UV transilluminator

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Transilluminator Tube for ULT40020622 - EACH

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Ultra Bright Blue LED Transilluminator - EACH

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SmartDoc band pass filter, 535nm, for imaging Green Stains on UV transilluminator

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UVPAD, LED Transilluminator, with mini Darkroom

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SmartDoc band UV Blocking Filter, optimized for use with E3100 transilluminator

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BluPAD, LED Transilluminator, with mini Darkroom

BP001CU Set
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Orange filter cover for mini LED transilluminator

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Dual LED Transilluminator Gel Documentation System

abx795001-10nmol 10 nmol Ask for price

Dual LED Transilluminator Gel Documentation System

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Accuris SmartDoc UV Blocking Mat - EACH

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Accuris

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Accuris

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Accuris

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Accuris myGel Mini Electrophoresis Syst w/ Transf - EACH

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Accuris Taq Plus, 250 units

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Accuris Taq Plus, 500 units

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Accuris Hydrophobic Filter - EACH

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Accuris NextPette Carousel - EACH

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Accuris 5mL Pipette Tips - PK100

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Accuris Taq Polymerase, 1000 units

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EUR 172.11

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Accuris Taq Polymerase, 6000 units

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Accuris qMax Probe,100 reactions

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Accuris Hot Start Taq, 1000 units

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EUR 383.06

Accuris Hot Start Taq, 500 units

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EUR 221.86

Accuris Hot Start Taq, 6000 units

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Accuris Orange Viewing Cover - EACH

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Accuris Extra Tubing Set 1m - EACH

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Accuris Taq Plus, sample, 50 units

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Filter for Accuris Microplate Reader

MR9600-490 1 PC
EUR 241.56

Filter for Accuris Microplate Reader

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Accuris SmartDoc 2.0 Imaging Enclosure

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Accuris SmartBlue Viewing Glasses - EACH

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Accuris Taq Polymerase, sample, 50 units

PR1000-S 1 PC
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Accuris A Balance 210g Read 0.0001g - EACH

BAL1345 EACH
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Accuris M1 Weight Set 1g-1000g - EACH

BAL1886 EACH
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Accuris Hot Start Taq, sample, 50 units

PR1000-HS-S 1 PC
EUR 7.31

Accuris Option Quick Disconnect Kit - EACH

ASP1093 EACH
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Accuris QuickSilver TBE Buffer Powder - PK50

EB1001 PK50
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Accuris SmartDoc 2.0 Imaging Enclosure - EACH

ELE1250 EACH
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Accuris Reversible Combs 22/12 Teeth - PK2

ELE1113 PK2
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ELE1115 PK2
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Accuris High Fidelity Master Mix, 200 rxns

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Accuris QuickSilver TAE Buffer Powder - PK100

EB1000 PK100
EUR 352.35

Accuris QuickSilver PBS Buffer Powder - PK100

EB1200 PK100
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Accuris Graduated PC Collection Bottle - EACH

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Accuris myVolt Mini Power Supply 230V - EACH

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Chromosomal abnormalities have been recognized by an optimised bioinformatics pipeline making use of copy quantity variation (CNV) detecting algorithm. On this research, we exhibit a complete workflow masking each wet- and dry-lab procedures supporting a clinically relevant technique for NIPGT-A that may be carried out inside 48 h, which is crucial for the same-cycle blastocyst switch. The described built-in method of non-invasive analysis of embryonic DNA content material of the tradition media can probably complement present pre-implantation genetic screening strategies.

The study of organelle DNA variability in alloplasmic barley lines in the NGS era

The study of organelle DNA variability in alloplasmic barley lines in the NGS era

Alloplasmic strains are an acceptable mannequin for finding out molecular coevolution and interrelations between genetic programs of plant cells. Complete chloroplast (cp) and mitochondrial (mt) genome sequences had been obtained by the MiSeq System (Illumina). Organelle DNA samples had been ready from a set of 12 alloplasmic barley strains with completely different cytoplasms of Hordeum vulgare ssp. spontaneum and H. vulgare ssp. vulgare, in addition to from their paternal varieties. A bioinformatic strategy for evaluation of NGS information obtained on an organellar DNA combine has been developed and verified.

A comparative research of Hordeum organelle genomes’ variability and disposition of polymorphic loci was performed. Eight forms of chloroplast DNA and 5 forms of mitochondrial DNA had been distinguished for the barley pattern set examined. These outcomes had been in contrast with the earlier information of a restriction fragment size polymorphism (RFLP) research of organelle DNAs for a similar materials. Previously established information a few discipline analysis of alloplasmic barley strains had been revised within the gentle of details about organelle genomes gained after NGS. Completely 17 polymorphic loci had been discovered at exons of chloroplast genomes.

Seven of the SNPs had been situated within the genes of the Ndh complicated. The nonsynonymous adjustments of nucleotides had been detected within the matK, rpoC1, ndhK, ndhG and infA genes. A few of the SNPs detected are very comparable in codon place and in the kind of amino acid substitution to the locations the place RNA modifying can happen. Thus, these outcomes define new views for the long run research of nuclear-cytoplasmic interactions in alloplasmic strains. Roughly 10%, 27%, and 63% of the 540 samples contained < 1500 GE, a variety of 1500-3000 GE, and > 3000 GE, which corresponded to a maximal assay sensitivity of two.0%, 0.5-0.1%, and 0.1-0.05% mutant allelic fraction, respectively.

The sensitivity and specificity had been measured for this BEAMing assay. The variety of mutant beads and mutant allelic fraction had been measured for every EGFR alteration and the extent of detection was established at 0.1% for a median of 2861 genome equal (GE) in every response utilizing HD780 horizon management DNA, in addition to by an inner high quality reference commonplace.  In a routine hospital setting, 11.4% of non-small cell lung most cancers tumors had been constructive at prognosis for EGFR alterations, whereas 43.7% samples harbored EGFR mutations at development, amongst which 40.3% expressed EGFR resistance mutations after first-line tyrosine kinase inhibitor remedy with first- and second-generation medication.

Molecular subtype prognosis of endometrial carcinoma: comparability of NGS panel and ProMisE classifier

The Most cancers Genome Atlas-based molecular classification of endometrial carcinoma (EC) has the potential to higher determine these sufferers whose illness is prone to behave in another way than predicted when utilizing conventional threat stratification, nonetheless, the optimum strategy to molecular subtype task in routine observe stays undetermined. The goal of this research was to check the outcomes of two completely different broadly obtainable approaches to prognosis of EC molecular subtype.
 EC from 60 sufferers, had been molecularly subclassified utilizing two completely different strategies; by performing the FoundationOne CDx Subsequent Technology Sequencing (NGS) panel and utilizing the Proactive Molecular Threat Classifier for Endometrial Most cancers (ProMisE) classifier and performing immunohistochemical stainings for MMR proteins and p53. MSI standing may very well be decided based mostly on the NGS panel ends in 53 of 60 tumors, so ProMisE and NGS molecular subtype task may very well be straight in contrast for these 53 tumors. Molecular subtype prognosis based mostly on NGS and ProMisE was in settlement for 52 of 53 tumors. One tumor was microsatellite steady (MSS) however confirmed lack of MLH1 and PMS2 expression.
 Molecular subtype prognosis of EC based mostly on NGS panel sequencing of formalin-fixed paraffin-embedded endometrial carcinomas and based mostly totally on immunostaining (ProMisE) yield equivalent ends in 98.1% (52/53, kappa – 0.97) of circumstances. Whereas outcomes are comparable utilizing these two approaches, every has benefits and drawbacks that may affect the selection of methodology for use in scientific observe. POLE mutation standing was in each settings derived from FoundationOne outcomes. Molecular classification based mostly on ProMisE was profitable for all 60 tumors.
The study of organelle DNA variability in alloplasmic barley lines in the NGS era

[NGS sequencing in barley breeding and genetic studies]

Barley (Hordeum vulgare L.) is the some of the necessary cereal species used as meals and feed crops, in addition to for malting and alcohol manufacturing. On the finish of the final century, conventional breeding methods had been complemented by means of DNA markers. Molecular markers have additionally been used extensively for molecular genetic mapping and QTL evaluation. In 2012, the barley genome sequencing was accomplished, which supplied a broad vary of recent alternatives – from a extra environment friendly seek for candidate genes controlling economically necessary traits to genomic choice.

The evaluation summarizes the outcomes of the research carried out after barley genome sequencing, which found new areas of barley genetics and breeding with excessive throughput screening and genotyping strategies. Throughout this era, intensive research geared toward identification of barley genomic loci related to economically necessary traits have been carried out; on-line databases and instruments for working with barley genomic information and their deposition have appeared and are being replenished. Lately, GWAS evaluation has been used for large-scale phenotypegenotype affiliation research, which has been broadly utilized in barley since 2010 because of the developed SNP-arrays, in addition to genotyping strategies based mostly on direct NGS sequencing of chosen fractions of the genome.

WUV-M20, UV Transilluminator, 312nm, 220V

3532198 1unit
EUR 1149.72

UltraBright UV Transilluminator, 302/365 nm

Q-MLB-16 1
EUR 1050

microDOC System with UV Transilluminator UVTS365 21x21cm 365nm - EACH

MOL3506 EACH
EUR 6189.75

Accuris™ UV Transilluminator, 230V input

E3000-E 1 PC
EUR 1255.7

Accuris™ UV Transilluminator, 230V input

BM0299 Ea
EUR 1567.2

UV Transilluminator 20 x 20 cm 302nm - EACH

ELE7584 EACH
EUR 1274.4

UV Transilluminator 25 x 30 cm 302nm - EACH

ELE7586 EACH
EUR 1742.85

Accuris MyView Compact UV Transilluminator 230V

ELE1261 EACH
EUR 875.52

UV Transilluminator 21 x 21cm 254nm - EACH

ULT4500 EACH
EUR 1455.3

UV Transilluminator 21 x 21cm 312nm - EACH

ULT4502 EACH
EUR 1386.45

UV Transilluminator 21 x 21cm 365nm - EACH

ULT4504 EACH
EUR 1386.45

UV Transilluminator 21 x 26cm 254nm - EACH

ULT4510 EACH
EUR 1899.16

UV Transilluminator 21 x 26cm 312nm - EACH

ULT4512 EACH
EUR 1899.16

UV Transilluminator 21 x 26cm 365nm - EACH

ULT4514 EACH
EUR 1899.16

UltraBright UV Transilluminator, 302 nm (Large View)

QMB-21 1
EUR 1150

UVPAD, LED Transilluminator, with mini Darkroom

UP001CU Set
EUR 900

Accuris MyView™ Compact UV Transilluminator, 230V

E3100-E 1 each
EUR 796.52

BluPAD, LED Transilluminator, with mini Darkroom

BP001CU Set
EUR 350

Accuris MyView™ Compact UV Transilluminator

E3100 1 each
EUR 796.52

UltraBright UV Transilluminator, 302/365 nm (Large View)

Q-MLB-21 1
EUR 1150

uv transilluminator 20x20cm, 312nm, 50/100% switch

UVTR2200 ea
EUR 1393.2

SmartDoc band UV Blocking Filter, optimized for use with E3100 transilluminator

E5001-UVBLOCK 1 each
EUR 55.59

SmartDoc band pass filter, 590nm, for imaging EtBr on UV transilluminator

E5001-590 1 PC
EUR 137.39

Transilluminator 365nm - EACH

ELE0032 EACH
EUR 1205.88

Transilluminator 302nm - EACH

ELE0034 EACH
EUR 1043.55

Transilluminator 254nm - EACH

ELE0036 EACH
EUR 1205.88

Transilluminator 302nm - EACH

ELE0052 EACH
EUR 1431

UV Transilluminator 21 x 21cm Dual Wave 254/365nm - EACH

ULT4506 EACH
EUR 1452.6

UV Transilluminator 21 x 21cm Dual Wave 254/312nm - EACH

ULT4508 EACH
EUR 1452.6

UV Transilluminator 21 x 26cm Dual Wave 254/365nm - EACH

ULT4516 EACH
EUR 1971.13

SmartDoc band pass filter, 535nm, for imaging Green Stains on UV transilluminator

E5001-535 1 PC
EUR 137.39

Transilluminator 230v 50Hz MW - EACH

ULT4102 EACH
EUR 1066.5

SmartBlue™ Transilluminator

E4000 1 each
EUR 665.24

Blue Light Transilluminator - EACH

ELE3416 EACH
EUR 868.05

EZ-Viewer LED Transilluminator

LED001 set
EUR 624

UltraBright LED Transilluminator, 470 nm

QLB-16 1
EUR 1050

SmartBlue™ Transilluminator, 230V input

E4000-E 1 PC
EUR 665.24

SmartBlue™ Mini Transilluminator

E4100 1 each
EUR 491.64

transilluminator led 20x12 cm + hood

BLOOK ea
EUR 696

Transilluminator 20x20cm 302/365 - EACH

ELE2104 EACH
EUR 1421.55

Transilluminator 25x30cm 302/365 - EACH

ELE2106 EACH
EUR 2018.25

Accuris SmartBlue Transilluminator 230V - EACH

ELE1262 EACH
EUR 967.95

SmartBlue™ Mini Transilluminator, 230V input

E4100-E 1 each
EUR 491.64

BluePad - Blue/White LED Transilluminator

Bp001CU 1 pcs
EUR 779

Transilluminator Tube for ULT40020622 - EACH

ULT4042 EACH
EUR 37.8

Ultra Bright Blue LED Transilluminator - EACH

ELE7526 EACH
EUR 1252.8

Orange filter cover for mini LED transilluminator

E1200-OC 1 each
EUR 40.1

Dual LED Transilluminator Gel Documentation System

abx795001-10nmol 10 nmol Ask for price

Dual LED Transilluminator Gel Documentation System

abx795001-5nmol 5 nmol
EUR 962.5

Phase slider Ph3 (100X) - EACH

MIC1586 EACH
EUR 101.35

Motic Phase Slider PH2 - EACH

MIC2916 EACH
EUR 111.63

chemiBENCH TM Chemiluminescent Imager

CBI-110 each
EUR 19500

Mini-Cute Imager Camera Hood

Q-MC-02 1
EUR 2950

Motic 3 Position Phase Slider - EACH

MIC2920 EACH
EUR 142.47

Analyser slider w rotating mount - EACH

MIC1584 EACH
EUR 188.01

Topmatic slider bag 350x450mm SDF30 - PK250

DD060559 PK250
EUR 287.55

SLIDER TITLE-PP-420x150mm-BLANK AC Signs

195908 Pack of 1 Pictogram(s)
EUR 14.36
Description: Description Dutch: Verwisselbare veiligheidsborden – Blanco titel; Description French: Panneaux de sécurité à glisser - Titre vierge

SLIDER TITLE-PP-296x150mm-BLANK AC Signs

195909 Pack of 1 Pictogram(s)
EUR 10.77
Description: Description Dutch: Verwisselbare veiligheidsborden – Blanco titel; Description French: Panneaux de sécurité à glisser - Titre vierge

SLIDER TITLE-PP-450x150mm-FR610 AC Signs

195913 Pack of 1 Pictogram(s)
EUR 15.95
Description: Description Dutch: Verwisselbare veiligheidsborden – Titel VEILIGHEIDSINSTRUCTIES - Consignes de sécurité; Description French: Panneaux de sécurité à glisser - Titre Consignes de sécurité

SLIDER TITLE-PP-420x150mm-FR610 AC Signs

195914 Pack of 1 Pictogram(s)
EUR 15.95
Description: Description Dutch: Verwisselbare veiligheidsborden – Titel VEILIGHEIDSINSTRUCTIES - Consignes de sécurité; Description French: Panneaux de sécurité à glisser - Titre Consignes de sécurité

SLIDER TITLE-PP-296x150mm-FR610 AC Signs

195915 Pack of 1 Pictogram(s)
EUR 11.96
Description: Description Dutch: Verwisselbare veiligheidsborden – Titel VEILIGHEIDSINSTRUCTIES - Consignes de sécurité; Description French: Panneaux de sécurité à glisser - Titre Consignes de sécurité

SLIDER TITLE-PP-450x150mm-NL340 AC Signs

195919 Pack of 1 Pictogram(s)
EUR 15.95
Description: Description Dutch: Verwisselbare veiligheidsborden – Titel VEILIGHEIDSINSTRUCTIES - Veiligheidsintructies; Description French: Panneaux de sécurité à glisser - Titre CONSIGNES DE SECURITE

SLIDER TITLE-PP-420x150mm-NL340 AC Signs

195920 Pack of 1 Pictogram(s)
EUR 15.95
Description: Description Dutch: Verwisselbare veiligheidsborden – Titel VEILIGHEIDSINSTRUCTIES - Veiligheidsintructies; Description French: Panneaux de sécurité à glisser - Titre CONSIGNES DE SECURITE

SLIDER TITLE-PP-296x150mm-NL340 AC Signs

195921 Pack of 1 Pictogram(s)
EUR 11.96
Description: Description Dutch: Verwisselbare veiligheidsborden – Titel VEILIGHEIDSINSTRUCTIES - Veiligheidsintructies; Description French: Panneaux de sécurité à glisser - Titre CONSIGNES DE SECURITE

SLIDER INSERT-PP-450x150mm-BLANK AC Signs

195905 Pack of 1 Pictogram(s)
EUR 14.36
Description: Description Dutch: Verwisselbare veiligheidsborden – Blanco insteekkaarten; Description French: Panneaux de sécurité à glisser - Inserts vierges

SLIDER INSERT-PP-210x297mm-BLANK AC Signs

195906 Pack of 1 Pictogram(s)
EUR 12.41
Description: Description Dutch: Verwisselbare veiligheidsborden – Blanco insteekkaarten; Description French: Panneaux de sécurité à glisser - Inserts vierges

SLIDER INSERT-PP-148x210mm-BLANK AC Signs

195907 Pack of 1 Pictogram(s)
EUR 9.78
Description: Description Dutch: Verwisselbare veiligheidsborden – Blanco insteekkaarten; Description French: Panneaux de sécurité à glisser - Inserts vierges

SLIDER BOARD-PVC-450x850mm-BLANK-LS AC Signs

195902 Pack of 1 Pictogram(s)
EUR 113.07
Description: Description Dutch: Verwisselbare veiligheidsborden – Blanco bord; Description French: Panneaux de sécurité à glisser - Panneau vierge

SLIDER BOARD-PVC-420x825mm-BLANK-4xA4 AC Signs

195903 Pack of 1 Pictogram(s)
EUR 104.53
Description: Description Dutch: Verwisselbare veiligheidsborden – Blanco bord; Description French: Panneaux de sécurité à glisser - Panneau vierge

SLIDER BOARD-PVC-296x650mm-BLANK-4xA5 AC Signs

195904 Pack of 1 Pictogram(s)
EUR 98.48
Description: Description Dutch: Verwisselbare veiligheidsborden – Blanco bord; Description French: Panneaux de sécurité à glisser - Panneau vierge

Fluorescent Particle Slide, UV, 10.0-14.0µm

FPS-10040 mL
EUR 98
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Slide Rack (24 Slides), Plastic Basket with Metal Handle

IMS002 1 ea.
EUR 102

Slides Staining Jar, with Ground - in

CG147-5X1NO 1 unit
EUR 124
Description: Slides Staining Jar, with Ground - in

Economical slide with cut edges - PK50

DD68763 PK50
EUR 8.1

KD-101-1 Slide Cabinet with Lock

KD-101-1 -
EUR 1800

Slide storing system with castor - EACH

MIC4524 EACH
EUR 773.55

Pogk (GFP-tagged) - Mouse pogo transposable element with KRAB domain (cDNA clone MGC:99912 IMAGE:6829796)

MG209555 10 µg Ask for price

Economical slide with ground edges 90 - PK50

DD68765 PK50
EUR 10.8

StainTray IHC Slide Staining System, Base with Clear Lid for 10 Slides

M918-1 -
EUR 185

StainTray IHC Slide Staining System, Base with Black Lid for 10 Slides

M918-2 -
EUR 185

StainTray IHC Slide Staining System, Base with Clear Lid for 20 Slides

M920-1 -
EUR 235

StainTray IHC Slide Staining System, Base with Black Lid for 20 Slides

M920-2 -
EUR 235

StainTray„¢ Slide Staining System - Base with Black Lid (10 Slide Capacity)

25498-1 1each
EUR 209

StainTray„¢ Slide Staining System - Base with Clear Lid (20 Slide Capacity)

25501-1 1each
EUR 308

StainTray„¢ Slide Staining System, Base with Black Lid (20 Slide Capacity)

25502-1 1each
EUR 208

StainTray-Base with Black Lid for 30 Slides

M922-2 -
EUR 345

StainTray-Base with Clear Lids for 30 Slides

M922-1 -
EUR 345

Total Count Dip Slide with Red Spot Dye BT2 - PK10

DIP1002 PK10
EUR 27.17

Stainless Steel Dish with Cover (for 30 Slide Holder)

IMS004 1 ea.
EUR 37.03

Kit of 100 slides Fast-Read 10 chambers with 1000 pipettes Pasteur - EACH

DD390498 EACH
EUR 267.3

GHAASEL slides with ground edges 2 frosted sides - PK50

DD69265 PK50
EUR 12.15

Simport Staintray System With Clear Lid 10 Slides - EACH

MIC4150 EACH
EUR 355.05

Simport Staintray System With Black Lid 10 Slides - EACH

MIC4152 EACH
EUR 373.95

Simport Staintray System With Clear Lid 20 Slides - EACH

MIC4160 EACH
EUR 411.75

Simport Staintray System With Black Lid 20 Slides - EACH

MIC4162 EACH
EUR 410.4

In-situ adapter (4 slides) for use with T5000-96 - EACH

MOL2018 EACH
EUR 839.7

MCTP1 (untagged)-Human multiple C2-domains with two transmembrane regions 1 (cDNA clone MGC:16292 IMAGE:3834212), complete cds

SC123509 10 µg Ask for price

Adenosis with focal ductal epithelium hyperplasia (5 slides/pack, single section/slide)

S-HuDAT072 1 unit
EUR 95

Vti1a (GFP-tagged) - Mouse vesicle transport through interaction with t-SNAREs homolog 1A (yeast) (cDNA clone MGC:102006 IMAGE:6839437)

MG202611 10 µg Ask for price

Villous adenoma with focal severe atypical hyperplasia (5 slides/pack, single section/slide)

S-HuDAT170 1 unit
EUR 95

Vti1a (Myc-DDK-tagged) - Mouse vesicle transport through interaction with t-SNAREs homolog 1A (yeast) (cDNA clone MGC:102006 IMAGE:6839437)

MR202611 10 µg Ask for price

nUVaClean™ UV Pipette Carousel, with germicidal UV lamp, 115V

P5590 1/pack
EUR 390.88
Description: nUVaClean UV pipette carousel with UV lamp

Fluorescent Particle Slide, UV, Yellow, Nile Red, & Purple, 10.0-14.0µm

FPS-100M4B mL
EUR 178.5
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Gemini Baskets x5 Black Sliders - EACH

HIS3616 EACH
EUR 182.25

Gemini Baskets x5 White Sliders - EACH

HIS3618 EACH
EUR 193.05

Fluorescent Particle Slide, UV, Yellow, Nile Red, and Blue, 10.0-14.0µm

FPS-100M4 mL
EUR 178.5
Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone.

Gspt1 (GFP-tagged) - Mouse G1 to S phase transition 1 (cDNA clone MGC:36230 IMAGE:4506483)

MG208005 10 µg Ask for price

Standard UV Quartz Cell with Teflon Stopper

SQ014 1 UNIT
EUR 176.69

Gspt1 (Myc-DDK-tagged) - Mouse G1 to S phase transition 1 (cDNA clone MGC:36230 IMAGE:4506483)

MR208005 10 µg Ask for price

AXYGEN® GEL TRAY 10 X 10 CM FOR USE WITH 10 CM GEL BOX, UV TRANSPARENT

HGB10-10-GT 1/pk
EUR 88.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 15 X 10 CM FOR USE WITH 15 CM GEL BOX, UV TRANSPARENT

HGB15-10-GT 1/pk
EUR 94.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 15 X 15 CM FOR USE WITH 15 CM GEL BOX, UV TRANSPARENT

HGB15-15-GT 1/pk
EUR 94.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 20 X 20 CM FOR USE WITH 20 CM GEL BOX, UV TRANSPARENT

HGB20-20-GT 1/pk
EUR 116.4
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 7 X 10 CM FOR USE WITH 7 CM GEL BOX, UV TRANSPARENT

HGB7-10-GT 1/pk
EUR 81.6
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 7 X 7 CM FOR USE WITH 7 CM GEL BOX, UV TRANSPARENT

HGB7-7-GT 1/pk
EUR 73.2
Description: Lab Equipment; Axygen Branded EQ

Lenti ORF clone of Gspt1 (mGFP-tagged) - Mouse G1 to S phase transition 1 (cDNA clone MGC:36230 IMAGE:4506483)

MR208005L4 10 µg Ask for price

Helz (untagged) - Mouse helicase with zinc finger domain (cDNA clone MGC:96862 IMAGE:30640711), (10ug)

MC206729 10 µg Ask for price

Lenti ORF clone of Gspt1 (Myc-DDK-tagged) - Mouse G1 to S phase transition 1 (cDNA clone MGC:36230 IMAGE:4506483)

MR208005L3 10 µg Ask for price

Sfmbt1 (GFP-tagged) - Mouse Scm-like with four mbt domains 1 (cDNA clone MGC:76655 IMAGE:30476111)

MG207437 10 µg Ask for price

Sfmbt1 (untagged) - Mouse Scm-like with four mbt domains 1 (cDNA clone MGC:76655 IMAGE:30476111), (10ug)

MC217796 10 µg Ask for price

Semi-Micro UV Quartz Cell With Frosted Walls and with Teflon Stopper

SQ294 1 UNIT
EUR 205.43

Cyclohexanone with UV Scanning Comp 5 Sol. - 250ML

CYHXNSC5W 250ML
EUR 188.01

Sfmbt1 (Myc-DDK-tagged) - Mouse Scm-like with four mbt domains 1 (cDNA clone MGC:76655 IMAGE:30476111)

MR207437 10 µg Ask for price

Lenti ORF particles, Gspt1 (GFP-tagged) - Mouse G1 to S phase transition 1 (cDNA clone MGC:36230 IMAGE:4506483), 200ul, >10^7 TU/mL

MR208005L4V 200 µl Ask for price

Zkscan1 (GFP-tagged) - Mouse zinc finger with KRAB and SCAN domains 1 (cDNA clone MGC:63357 IMAGE:6406518)

MG207820 10 µg Ask for price

Zkscan5 (GFP-tagged) - Mouse zinc finger with KRAB and SCAN domains 5 (cDNA clone MGC:67150 IMAGE:5715760)

MG210432 10 µg Ask for price

Lenti ORF particles, Gspt1 (Myc-DDK-tagged) - Mouse G1 to S phase transition 1 (cDNA clone MGC:36230 IMAGE:4506483), 200ul, >10^7 TU/mL

MR208005L3V 200 µl Ask for price

Zkscan2 (GFP-tagged) - Mouse zinc finger with KRAB and SCAN domains 2 (cDNA clone IMAGE:5367422)

MG203997 10 µg Ask for price

Ifih1 (GFP-tagged) - Mouse interferon induced with helicase C domain 1 (cDNA clone MGC:90959 IMAGE:3597815)

MG211363 10 µg Ask for price

Wac (GFP-tagged) - Mouse WW domain containing adaptor with coiled-coil (cDNA clone MGC:90590 IMAGE:6848738)

MG209727 10 µg Ask for price

Cgref1 (GFP-tagged) - Mouse cell growth regulator with EF hand domain 1 (cDNA clone MGC:28551 IMAGE:4206019)

MG203802 10 µg Ask for price

Zkscan2 (untagged) - Mouse zinc finger with KRAB and SCAN domains 2 (cDNA clone IMAGE:5367422), (10ug)

MC218556 10 µg Ask for price

Wac (untagged) - Mouse WW domain containing adaptor with coiled-coil (cDNA clone MGC:90590 IMAGE:6848738), (10ug)

MC206098 10 µg Ask for price

Rbpms (GFP-tagged) - Mouse RNA binding protein gene with multiple splicing (cDNA clone MGC:40656 IMAGE:4225078)

MG201952 10 µg Ask for price

Rbpms2 (GFP-tagged) - Mouse RNA binding protein with multiple splicing 2 (cDNA clone MGC:28665 IMAGE:4236661)

MG202168 10 µg Ask for price

Ralgps2 (untagged) - Mouse Ral GEF with PH domain and SH3 binding motif 2 (cDNA clone MGC:60456 IMAGE:30051209), (10ug)

MC205985 10 µg Ask for price

Ralgps1 (GFP-tagged) - Mouse Ral GEF with PH domain and SH3 binding motif 1 (cDNA clone MGC:99991 IMAGE:30536315)

MG208271 10 µg Ask for price

Ralgps2 (GFP-tagged) - Mouse Ral GEF with PH domain and SH3 binding motif 2 (cDNA clone MGC:58073 IMAGE:6811441)

MG208924 10 µg Ask for price

Ralgps1 (untagged) - Mouse Ral GEF with PH domain and SH3 binding motif 1 (cDNA clone MGC:99991 IMAGE:30536315), (10ug)

MC218644 10 µg Ask for price

Lobular hyperplasia without atypia (5 slides/pack, single section/slide)

S-HuDAT079 1 unit
EUR 95

MultiSUB Midi 96 with UV tray comb block combs and dams - EACH

MSMIDI96 EACH
EUR 459.73

Chfr (untagged) - Mouse checkpoint with forkhead and ring finger domains (cDNA clone MGC:59419 IMAGE:6510480), (10ug)

MC206709 10 µg Ask for price

CHMP4C (untagged)-Human Snf7 homologue associated with Alix 3 (cDNA clone MGC:22825 IMAGE:3828410), complete cds

SC122460 10 µg Ask for price

Aggf1 (untagged) - Mouse angiogenic factor with G patch and FHA domains 1 (cDNA clone MGC:63399 IMAGE:5716440), (10ug)

MC206687 10 µg Ask for price

WSE-6370 LGIII lite with UV set CE marked

2006370 each
EUR 154.1
Description: 6.0mega Pixel Cooled CCD with F0.8 Main unit/white flat LED/UV kit

Thus far, greater than 80 papers have been revealed that describe the outcomes of the GWAS evaluation in barley. SNP identification related to economically necessary traits and their transformation into CAPS or KASP markers handy for screening choice materials considerably expands the probabilities of marker-assisted choice of barley. As well as, the presently obtainable data on potential goal genes and the standard of the entire barley genome sequence gives base for making use of genome modifying applied sciences to create materials for the creation of types with desired properties.

A Rapid NGS-Based Preimplantation Genetic Testing for Chromosomal Abnormalities in Day-3 Blastomere Biopsy Allows Embryo Transfer Within the Same Treatment Cycle

A Rapid NGS-Based Preimplantation Genetic Testing for Chromosomal Abnormalities in Day-3 Blastomere Biopsy Allows Embryo Transfer Within the Same Treatment Cycle

These days, many of the preimplantation genetic testing (PGT) is carried out with a method of complete chromosome screening and trophectoderm biopsy. However, sufferers with ovarian insufficiency could not have competent blastocysts. Within the current examine, we aimed to ascertain the worth of a number of annealing and looping-based amplification cycle (MALBAC)-based next-generation sequencing (NGS) for PGT in day-Three embryos. A complete of 94.3% (1168/1239) of embryos yielded informative outcomes, and the general embryo euploid charge was 21.9% (256/1168).

Total, 225 embryos have been transferred in 169 cycles with a medical being pregnant charge of 49.1% (83/169). The stay start and implantation charges have been 47.3% (80/169) and 44.4% (100/225), respectively. Double embryos switch confirmed greater medical being pregnant and stay start charges in contrast with single embryo switch, however the implantation charges have been comparable (44.2% vs. 44.6%, P > 0.05). The euploid charge for reciprocal translocations (16.1%) was considerably decrease than that for Robertsonian translocations (28.0%, P < 0.01) and inversions (28.0%, P < 0.01). Nonetheless, greater percentages of embryos with de novo abnormalities have been noticed with Robertsonian translocations (23.3%, P < 0.01) and inversions (30.5%, P < 0.01) than with reciprocal translocations (11.6%).

From Sep. 2016 to Aug. 2018, a complete of six {couples} participated on this examine. 4 instances carried DMD exon deletions and two carried exon duplications. Trophectoderm cells have been biopsied at day 5 or 6 and NGS was used within the genetic testing of the biopsied cells after whole-genome amplification. We developed a brand new method-DIRected Embryonic Cell Testing of Exon Deletion/Duplication (DIRECTED) to instantly detect the single-gene mutation by NGS. Linage evaluation based mostly on single-nucleotide polymorphism (SNP) was used to validate the outcomes from DIRECTED.

 Within the 4 deletion instances, DIRECTED was used to detect DMD exon deletion in 16 biopsied embryos. All DIRECTED outcomes have been in line with linkage evaluation, indicating this technique was dependable in detecting deletions round 1 Mb. Within the two instances carrying exon duplications, no blastocyst was obtained for biopsy. Nonetheless, preliminary experiment outcomes urged that DIRECTED may be used for direct detection of exon duplications in embryos. We demonstrated that NGS for PGT on day-Three embryos is an efficient medical software, significantly for sufferers with a diminished ovarian reserve and restricted embryos.

Subsequent-Era Sequencing (NGS)-Primarily based Preimplantation Genetic Testing for Aneuploidy (PGT-A) of Trophectoderm Biopsy for Recurrent Implantation Failure (RIF) Sufferers: a Retrospective Research

Recurrent implantation failure (RIF) is an intrigue situation throughout in vitro fertilization (IVF) cycles or intracytoplasmic sperm injection (ICSI) remedies. The aim of this retrospective examine is to discover the worth of next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A) of trophectoderm biopsy within the medical outcomes for RIF sufferers with superior age. A complete of 265 RIF sufferers, who underwent 346 oocyte retrieval cycles and 250 PGT-A cycles, have been categorised as two teams in keeping with the feminine age, together with < 38 and ≥ 38 years outdated teams.

The 2 teams have been statistically comparable in baseline traits. The part of aneuploid embryos was considerably greater in superior age group than in youthful age group (68.9 vs 39.9%, P < 0.001). However there have been no statistically vital variations in being pregnant charge (43.5 vs 64.7%), medical being pregnant charge (39.1 vs 48.0%), implantation charge (39.1 vs 51.0%), and miscarriage charge (4.Three vs 7.8%) per embryo switch (ET) between the 2 teams. Outcomes counsel that the embryo-related issue performs an important position in RIF. Maternal age doesn’t affect the implantation potential of euploid blastocysts.

The NGS-based PGT-A involving trophectoderm biopsy is efficacious for RIF sufferers of superior age by enhancing their medical outcomes. In conclusion, the NGS-based PGT-A involving trophectoderm biopsy could symbolize a invaluable complement to the present RIF administration. Nonetheless, these findings ought to be additional validated in a well-designed randomized managed trial.

A Rapid NGS-Based Preimplantation Genetic Testing for Chromosomal Abnormalities in Day-3 Blastomere Biopsy Allows Embryo Transfer Within the Same Treatment Cycle

Sanger sequencing is not all the time needed based mostly on a single-center validation of 1109 NGS variants in 825 medical exomes

Regardless of the improved accuracy of next-generation sequencing (NGS), it’s extensively accepted that variants have to be validated utilizing Sanger sequencing earlier than reporting. Validation of all NGS variants significantly will increase the turnaround time and prices of medical prognosis. We comprehensively assessed this want in 1109 variants from 825 medical exomes, the biggest pattern set up to now assessed utilizing Illumina chemistry reported. With a concordance of 100%, we conclude that Sanger sequencing might be very helpful as an inside high quality management, however not a lot as a verification technique for high-quality single-nucleotide and small insertion/deletions variants.

Laboratories would possibly validate and set up their very own thresholds earlier than discontinuing Sanger affirmation research. We additionally increase and validate 23 copy quantity variations detected by exome sequencing in 20 samples, observing a concordance of 95.65%.  47 sufferers have been enrolled for additional evaluation. A last prognosis was accessible in 27 instances together with Eight adverse controls. In 43/47 (91.5%) of sufferers a KRAS- and/or GNAS-mutation was identified by NGS. 27.0% of the KRAS-mutated and 10.0% of the GNAS-mutated lesions harbored a number of mutations. KRAS/GNAS-testing by NGS, cytology, and CEA had a sensitivity and specificity of 94.7/100%, 38.1/100% and 42.1/75.0%, respectively.

UltraBright UV Transilluminator, 302/365 nm (Large View)

Q-MLB-21 1
EUR 1150

UltraBright UV Transilluminator, 302 nm

QMB-16 1
EUR 1050

UltraBright UV Transilluminator, 302/365 nm

Q-MLB-16 1
EUR 1050

Ultra Bright Blue LED Transilluminator - EACH

ELE7526 EACH
EUR 1252.8

EZ-Viewer LED Transilluminator

LED001 set
EUR 624

transilluminator led 20x12 cm + hood

BLOOK ea
EUR 696

BluePad - Blue/White LED Transilluminator

Bp001CU 1 pcs
EUR 779

Orange filter cover for mini LED transilluminator

E1200-OC 1 each
EUR 40.1

UVPAD, LED Transilluminator, with mini Darkroom

UP001CU Set
EUR 900

BluPAD, LED Transilluminator, with mini Darkroom

BP001CU Set
EUR 350

Dual LED Transilluminator Gel Documentation System

abx795001-10nmol 10 nmol Ask for price

Dual LED Transilluminator Gel Documentation System

abx795001-5nmol 5 nmol
EUR 962.5

Mini-Imager Dual UV/LED Transilluminator, 302 nm/470 nm

Q-MI-01 1
EUR 4650

Transilluminator Tube for ULT40020622 - EACH

ULT4042 EACH
EUR 37.8

Transilluminator 365nm - EACH

ELE0032 EACH
EUR 1205.88

Transilluminator 302nm - EACH

ELE0034 EACH
EUR 1043.55

Transilluminator 254nm - EACH

ELE0036 EACH
EUR 1205.88

Transilluminator 302nm - EACH

ELE0052 EACH
EUR 1431

Transilluminator 230v 50Hz MW - EACH

ULT4102 EACH
EUR 1066.5

Hi-UV Max Transilluminator

LA1067-1NO 1 unit
EUR 1333.72
Description: Hi-UV Max Transilluminator

SmartBlue™ Transilluminator

E4000 1 each
EUR 665.24

UV Transilluminator 302nm 15x11 - EACH

ELE7596 EACH
EUR 869.53

Accuris™ UV Transilluminator

E3000 1 each
EUR 1255.7

Accuris™ UV Transilluminator

BM0298 Ea
EUR 1567.2

Accuris UV Transilluminator 230V - EACH

ELE1260 EACH
EUR 1788.75

Blue Light Transilluminator - EACH

ELE3416 EACH
EUR 868.05

WUV-M20, UV Transilluminator, 312nm, 100V

3532197 1unit
EUR 1149.72

WUV-M20, UV Transilluminator, 312nm, 220V

3532198 1unit
EUR 1149.72

SmartBlue™ Transilluminator, 230V input

E4000-E 1 PC
EUR 665.24

UV Transilluminator 20 x 20 cm 302nm - EACH

ELE7584 EACH
EUR 1274.4

UV Transilluminator 25 x 30 cm 302nm - EACH

ELE7586 EACH
EUR 1742.85

Accuris™ UV Transilluminator, 230V input

E3000-E 1 PC
EUR 1255.7

Accuris™ UV Transilluminator, 230V input

BM0299 Ea
EUR 1567.2

SmartBlue™ Mini Transilluminator

E4100 1 each
EUR 491.64

Transilluminator 20x20cm 302/365 - EACH

ELE2104 EACH
EUR 1421.55

Transilluminator 25x30cm 302/365 - EACH

ELE2106 EACH
EUR 2018.25

Accuris SmartBlue Transilluminator 230V - EACH

ELE1262 EACH
EUR 967.95

SmartBlue™ Mini Transilluminator, 230V input

E4100-E 1 each
EUR 491.64

UV Transilluminator 21 x 21cm 254nm - EACH

ULT4500 EACH
EUR 1455.3

UV Transilluminator 21 x 21cm 312nm - EACH

ULT4502 EACH
EUR 1386.45

UV Transilluminator 21 x 21cm 365nm - EACH

ULT4504 EACH
EUR 1386.45

UV Transilluminator 21 x 26cm 254nm - EACH

ULT4510 EACH
EUR 1899.16

UV Transilluminator 21 x 26cm 312nm - EACH

ULT4512 EACH
EUR 1899.16

UV Transilluminator 21 x 26cm 365nm - EACH

ULT4514 EACH
EUR 1899.16

Accuris MyView Compact UV Transilluminator 230V

ELE1261 EACH
EUR 875.52

Accuris MyView™ Compact UV Transilluminator, 230V

E3100-E 1 each
EUR 796.52

uv transilluminator 20x20cm, 312nm, 50/100% switch

UVTR2200 ea
EUR 1393.2

Accuris MyView™ Compact UV Transilluminator

E3100 1 each
EUR 796.52

UV Transilluminator 21 x 21cm Dual Wave 254/365nm - EACH

ULT4506 EACH
EUR 1452.6

UV Transilluminator 21 x 21cm Dual Wave 254/312nm - EACH

ULT4508 EACH
EUR 1452.6

UV Transilluminator 21 x 26cm Dual Wave 254/365nm - EACH

ULT4516 EACH
EUR 1971.13

SmartDoc band pass filter, 590nm, for imaging EtBr on UV transilluminator

E5001-590 1 PC
EUR 137.39

microDOC System with UV Transilluminator UVTS365 21x21cm 365nm - EACH

MOL3506 EACH
EUR 6189.75

SmartDoc band pass filter, 535nm, for imaging Green Stains on UV transilluminator

E5001-535 1 PC
EUR 137.39

SmartDoc band UV Blocking Filter, optimized for use with E3100 transilluminator

E5001-UVBLOCK 1 each
EUR 55.59

Replacement cables for CSQ Large Format Vertical Units - PK2

CSLCAB2 PK2
EUR 159.3

UltraBrite? Red IHC chromogen (AP)

M1305-30 each
EUR 418.8

UltraBrite? Blue IHC chromogen (AP)

M1307-30 each
EUR 444

UltraBrite? Red IHC chromogen (HRP)

M1312-30 each
EUR 444

UltraBrite? Red IHC chromogen (AP Plus)

M1306-30 each
EUR 836.4

UltraBrite? Blue IHC chromogen (HRP)

M1308-30 each
EUR 548.4

UltraBrite? Green IHC chromogen (AP)

M1309-30 each
EUR 510

UltraBrite? Black IHC chromogen (HRP)

M1311-30 each
EUR 548.4

UltraBrite? Yellow IHC chromogen (HRP)

M1310-30 each
EUR 548.4

LED Transiluminator - 470nm - EACH

ELE3414 EACH
EUR 496.8

Cryo Glove Ultra Cold Large - 1PR

CRY9004 1PR
EUR 248.4

Blue Nitrex Ultra Sensitive 240mm Large

COV2027 PK2000
EUR 182.4

UltraSlim LED Illuminator, 470 nm (White)

Q-SLB-01W 1
EUR 775

Sealing Mats for 96 Well Format

GP501 5 mats
EUR 176.4

Tubulin (HTS format, porcine, 8 assays)

HTS03-A 1 x 4 mg
EUR 420.16

Tubulin (HTS format, porcine, 96 assays)

HTS03-B 1 x 40 mg
EUR 1901.12

Pressure Sealing Mats for 384 Well Format

GP504 5 mats
EUR 235.2

LARGE (untagged)-Human like-glycosyltransferase (LARGE), transcript variant 2

SC120425 10 µg Ask for price

LARGE (untagged)-Human like-glycosyltransferase (LARGE), transcript variant 1

SC117185 10 µg Ask for price

LARGE (GFP-tagged) - Human like-glycosyltransferase (LARGE), transcript variant 2

RG223788 10 µg Ask for price

LARGE (GFP-tagged) - Human like-glycosyltransferase (LARGE), transcript variant 1

RG217876 10 µg Ask for price

LARGE (Myc-DDK-tagged)-Human like-glycosyltransferase (LARGE), transcript variant 1

RC217876 10 µg Ask for price

LARGE (Myc-DDK-tagged)-Human like-glycosyltransferase (LARGE), transcript variant 2

RC223788 10 µg Ask for price

Anti-CD19-Anti-CD3 IgG format Bispecific Antibody

101076-1 50 µg
EUR 390
Description: Anti-CD19-Anti-CD3 IgG format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of CD19-CHO cells (BPS Bioscience #79561-H) that overexpress CD19.

Anti-CD19-Anti-CD3 IgG format Bispecific Antibody

101076-2 100 µg
EUR 490
Description: Anti-CD19-Anti-CD3 IgG format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of CD19-CHO cells (BPS Bioscience #79561-H) that overexpress CD19.

Anti-PSMA-Anti-CD3 IgG format Bispecific Antibody

101242-1 50 µg
EUR 390
Description: Anti-PSMA-Anti-CD3 IgG format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of PSMA-CHO cells (BPS Bioscience #79641-H).PSMA (Prostate-Specific Membrane antigen), also known as FLOH1 (folate hydrolase 1) and NAALADase I (N-acetyl-L-aspartyl-L-glutamate peptidase I) is a transmembrane protein highly expressed in the intestine, the prostate, and the nervous system. The protein is a glutamate carboxypeptidase involved in folate metabolism and may be involved in pathological conditions such as hyperhomocysteinemia (intestine) and glutamate toxicity (nervous system). PSMA is overexpressed in prostate cancer cells and is the target of an increasing number of diagnostic and therapeutic approaches used for the treatment of prostate cancer.

Anti-PSMA-Anti-CD3 IgG format Bispecific Antibody

101242-2 100 µg
EUR 490
Description: Anti-PSMA-Anti-CD3 IgG format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of PSMA-CHO cells (BPS Bioscience #79641-H).PSMA (Prostate-Specific Membrane antigen), also known as FLOH1 (folate hydrolase 1) and NAALADase I (N-acetyl-L-aspartyl-L-glutamate peptidase I) is a transmembrane protein highly expressed in the intestine, the prostate, and the nervous system. The protein is a glutamate carboxypeptidase involved in folate metabolism and may be involved in pathological conditions such as hyperhomocysteinemia (intestine) and glutamate toxicity (nervous system). PSMA is overexpressed in prostate cancer cells and is the target of an increasing number of diagnostic and therapeutic approaches used for the treatment of prostate cancer.

Anti-CD20-Anti-CD3 IgM format Bispecific Antibody

100860-1 50 µg
EUR 390
Description: His-tagged Anti-CD20-Anti-CD3 IgM format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of CD20-CHO cells (BPS Bioscience #79624-H).  The IgM Fc region is pentameric, so there are 5 copies of the anti-CD20 antibodies and J chain has anti-CD3 antibody. 

Anti-CD20-Anti-CD3 IgM format Bispecific Antibody

100860-2 100 µg
EUR 490
Description: His-tagged Anti-CD20-Anti-CD3 IgM format bispecific antibody is a purified recombinant human bispecific antibody with T cell Engager. This bispecific antibody has been tested for specific activity in the functional reporter assay using NFAT-luc reporter Jurkat cell line (BPS Bioscience #60621) in the presence of CD20-CHO cells (BPS Bioscience #79624-H).  The IgM Fc region is pentameric, so there are 5 copies of the anti-CD20 antibodies and J chain has anti-CD3 antibody. 

CRISPR/Cas9 Kinase Knockout Lentivirus Library (Array Format)

78487 200 µl x 649
EUR 7700
Description: The CRISPR/Cas9 Kinase Knockout Lentivirus Library (Array Format) targets 619 human kinases and pseudo-kinases.bpsbioscience.com/media/wysiwyg/Kinases/Kinase_Library_-_List_Kinases_Pseudokinases_06-15-2022.xlsx Download the table to view all available kinases. The Array consists of a series of vials, with each vial containing a mixture of integrating CRISPR/Cas9 lentiviral particles targeting 5 sgRNAs for a specific gene (1 vial per gene, 5 sgRNAs per gene). The Array also includes a total of 150 control sgRNAs that do not target any gene (combined into 30 vials containing 5 control sgRNAs per vial). Thus, the Array contains a total of 649 vials and 3,245 sgRNAs.The lentiviruses are replication incompetent, VSV-G pseudotyped lentiviral particles ready to infect almost all types of mammalian cells, including primary and non-dividing cells. The SIN (self-inactivation) lentiviral backbone contains the Cas9 gene (Streptococcus pyogenes CRISPR associated protein 9) driven by an EF1a promoter, an sgRNA driven by a U6 promoter, and a puromycin selection marker.The lentiviruses integrate randomly into the cellular genome to express both Cas9 and the sgRNAs. Because the lentiviruses contain Cas9, they can be used in any target cell regardless of whether the cells already express Cas9. Puromycin selection ensures high expression of both Cas9 and the sgRNAs. Knockout efficiencies will depend on the cell type and the gene of interest. Stable CRISPR/Cas9 knockout cell lines can also be generated following limiting dilution.The library is delivered with a User Manual booklet.

Calcium Phasphate Transfection Kit (Large)

TBS8201-2 Kit
EUR 328

Transfer Pipette 15mL Large Bulb - PK250

ARG1836 PK250
EUR 38.63

LARGE

CSB-CL012749HU 10 μg plasmid + 200μl Glycerol Ask for price

96 individual caps in sheet format blue TPE pierceable - PK50

PCR1123 PK50
EUR 625.05

ReadiUseâ„¢ 6-Color Human TBNK Antibody Kit *Dry Reagent Format*

90010-5Tests 5 Tests
EUR 301
Description: The ReadiUse™ 6-Color Human TBNK Antibody Kit for flow cytometry utilizes dried multicolor beads to delineate principal lymphocyte subsets - CD4+ T cells, CD8+ T cells, B cells, and NK cells – in whole blood specimens.

ReadiUseâ„¢ 6-Color Human TBNK Antibody Kit *Dry Reagent Format*

90011-25Tests 25 Tests
EUR 969
Description: The ReadiUse™ 6-Color Human TBNK Antibody Kit for flow cytometry utilizes dried multicolor beads to delineate principal lymphocyte subsets - CD4+ T cells, CD8+ T cells, B cells, and NK cells – in whole blood specimens.

CytoSelect™ 96-Well Phagocytosis Assay (E. coli, Colorimetric Format)

CBA-222 96 assays
EUR 595

Mouse Monoclonal anti-human HAI-1 (biotin-conjugated format only)

hAP-0322B 100ug
EUR 250

Transfer Pipette 7.5mL Large Bulb Graduated - PK500

ARG1864 PK500
EUR 39.15

ELISA kit for Human LAT1 (Large Neutral Amino Acid Transporter 1)

ELK2451 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Large Neutral Amino Acid Transporter 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

1.1ml Cluster Tubes, Individual Tube Format,Non-Sterile, 960/pk, 4800/cs

628111 4800 pcs/cs
EUR 52.47
Description: 1.1ml Cluster Tubes, Individual Tube Format,Non-Sterile, 960/pk, 4800/cs

Microsomal triglyceride transfer protein large subunit

AP85473 1mg
EUR 2640

Microsomal triglyceride transfer protein large subunit

AP85497 1mg
EUR 2640

Microsomal triglyceride transfer protein large subunit

AP85702 1mg
EUR 2640

Microsomal triglyceride transfer protein large subunit

AP86007 1mg
EUR 2640

LARGE siRNA

20-abx922269
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

LARGE siRNA

20-abx922270
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

1.1ml Cluster Tubes, 8-Tube Strip Format,Non-Sterile, 120/pk,600/cs

628121 600 pcs/cs
EUR 49.28
Description: 1.1ml Cluster Tubes, 8-Tube Strip Format,Non-Sterile, 120/pk,600/cs

LARGE (LARGE1) (35-142) mouse monoclonal antibody, clone LARGE-02, PE

AM26764RP-N 100 µg Ask for price

1.1ml Cluster Tubes, 12-Tube Strip Format,Non-Sterile, 80/pk,400/cs

628131 400 pcs/cs
EUR 43.34
Description: 1.1ml Cluster Tubes, 12-Tube Strip Format,Non-Sterile, 80/pk,400/cs

LARGE Peptide

42-561P 0.1 mg
EUR 405.6
Description: (NT) LARGE Peptide

LARGE Peptide

42-560P 0.1 mg
EUR 405.6
Description: (IN) LARGE Peptide

1.1ml Cluster Tubes, Individual Tube Format,Sterile, 96/box, 960/pk,4800/cs

628114 4800 pcs/cs
EUR 95.15
Description: 1.1ml Cluster Tubes, Individual Tube Format,Sterile, 96/box, 960/pk,4800/cs

LARGE Antibody

E314008 200ul
EUR 275
Description: Available in various conjugation types.

LARGE antibody

70R-6856 50 ug
EUR 467
Description: Rabbit polyclonal LARGE antibody raised against the middle region of LARGE

LARGE Antibody

GWB-MQ476H 50ug Ask for price

LARGE Antibody

R35864-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Like-acetylglucosaminyltransferase

LARGE (LARGE1) (35-142) mouse monoclonal antibody, clone LARGE-02, Purified

AM26764PU-N 100 µg Ask for price

Large (GFP-tagged) - Mouse like-glycosyltransferase (Large)

MG210487 10 µg Ask for price

1.1ml Cluster Tubes, 8-Tube Strip Format, Sterile, 12/box,120/pk,600/cs

628124 600 pcs/cs
EUR 96.47
Description: 1.1ml Cluster Tubes, 8-Tube Strip Format, Sterile, 12/box,120/pk,600/cs

Lenti ORF particles, LARGE (mGFP-tagged) - Human like-glycosyltransferase (LARGE), transcript variant 1, 200ul, >10^7 TU/mL

RC217876L4V 200 µl Ask for price

Lenti ORF particles, LARGE (mGFP-tagged) - Human like-glycosyltransferase (LARGE), transcript variant 2, 200ul, >10^7 TU/mL

RC223788L4V 200 µl Ask for price

Large (untagged) - Mouse like-glycosyltransferase (Large), (10ug)

MC221370 10 µg Ask for price

Large Neutral Amino Acid Transporter 1 (LAT1) Antibody

abx432915-200ul 200 ul
EUR 460.8

Large Neutral Amino Acid Transporter 1 (LAT1) Antibody

abx430256-200ul 200 ul
EUR 460.8

Transfer Pipette 8mL General Purpose Large Bulb - PK400

ARG1868 PK400
EUR 51.3

Large Neutral Amino Acid Transporter 1 (LAT1) Antibody

20-abx173311
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

Large Neutral Amino Acid Transporter 1 (LAT1) Antibody

20-abx177312
  • Ask for price
  • Ask for price
  • 1 mg
  • 200 ug

Formaldehyde, 10%, methanol free, Ultra Pure

04018-1 1L
EUR 201
Description: 50-00-0

Formaldehyde, 10%, methanol free, Ultra Pure

04018-4 4x1 L
EUR 675
Description: 50-00-0

Formaldehyde, 16%, methanol free, Ultra Pure

18814-10 10x10ml
EUR 109
Description: 50-00-0

Formaldehyde, 16%, methanol free, Ultra Pure

18814-20 20x10ml
EUR 192
Description: 50-00-0

1.1ml Cluster Tubes, 12-Tube Strip Format, Sterile, 8/box,80/pk,400/cs

628134 400 pcs/cs
EUR 89.98
Description: 1.1ml Cluster Tubes, 12-Tube Strip Format, Sterile, 8/box,80/pk,400/cs

Transfer Pipette 5mL Large Bulb Double Graduated - PK500

ARG1852 PK500
EUR 35.54

Lenti ORF particles, LARGE (Myc-DDK tagged) - Human like-glycosyltransferase (LARGE), transcript variant 1, 200ul, >10^7 TU/mL

RC217876L3V 200 µl Ask for price

Lenti ORF particles, LARGE (Myc-DDK tagged) - Human like-glycosyltransferase (LARGE), transcript variant 2, 200ul, >10^7 TU/mL

RC223788L3V 200 µl Ask for price

Transfer Pipette 5mL Large Bulb Graduated STERILE - PK500

ARG1858 PK500
EUR 47.88

Haier Stainless steel side loading rack for 2 cryo boxes 4x4 format - EACH

SLS1110 EACH
EUR 229.5

Haier Stainless steel drawer style rack for 2 cryo boxes 4x4 format - EACH

SLS1112 EACH
EUR 241.65

Haier Stainless steel side loading rack for 2 cryo boxes 5x4 format - EACH

SLS1114 EACH
EUR 244.35

Haier Stainless steel drawer style rack for 2 cryo boxes 5x4 format - EACH

SLS1116 EACH
EUR 245.7

Haier Stainless steel side loading rack for 2 cryo boxes 5x5 format - EACH

SLS1118 EACH
EUR 252.45

Haier Stainless steel drawer style rack for 2 cryo boxes 5x5 format - EACH

SLS1120 EACH
EUR 253.8

Flystuff (59-101) Embryo Collection Cage - Large - For 100mm Petri Dishes - PK4

FLY1214 PK4
EUR 312.85

Transfer Pipette 5mL Large Bulb Graduated to 1mL - PK500

ARG1856 PK500
EUR 45.9

Human Large Neutral Amino Acid Transporter 1 ELISA Kit

IHULAT1KT each
EUR 733
Description: Human Large Neutral Amino Acid Transporter 1 ELISA Kit

Simian Virus 40 large T (SV40 large T) ELISA Kit

abx055954-100g 100 µg Ask for price

Simian Virus 40 large T (SV40 large T) ELISA Kit

abx055954-200g 200 µg Ask for price

Simian Virus 40 large T (SV40 large T) ELISA Kit

abx055954-50g 50 µg
EUR 493.75

Cart for Large Platform - EACH

ZSCART001 EACH
EUR 2679.09

CytoSelect 24-Well Cell Migration Assay (5 µm, Fluorometric Format), Trial Size

CBA-102-T 4 assays
EUR 358.8
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

KRAS/GNAS-testing was considerably superior to CEA (P = 0,0209) and cytology (P = 0.0016). In conclusion, KRAS/GNAS-testing by deep focused NGS is an acceptable technique to tell apart mucinous from non-mucinous pancreatic lesions, suggesting its utilization as a single diagnostic check. Outcomes have to be confirmed in a bigger cohort. This text is protected by copyright. All rights reserved.

IHC versus FISH versus NGS to detect ALK gene rearrangement in NSCLC: all questions answered?

IHC versus FISH versus NGS to detect ALK gene rearrangement in NSCLC: all questions answered?

Anaplastic lymphoma kinase (ALK) rearranged non-small cell lung carcinoma (NSCLC) is a definite molecular subtype and speedy approval of ALK tyrosine kinase inhibitors (TKIs) has necessitated speedy and delicate diagnostic modalities for the detection of this alteration. Gene rearrangements might be recognized utilizing many strategies together with fluorescence in situ hybridisation (FISH), reverse transcriptase-PCR, next-generation sequencing (NGS) and immunohistochemistry (IHC) for fusion oncoprotein expression. We aimed to find out the concordance between IHC, FISH and NGS for ALK biomarker detection, and decide variations in sensitivity, and survival outcomes.
We analysed the concordance between IHC utilizing D5F3 monoclonal antibody, FISH (break-apart) and NGS utilizing a customized panel containing 71 totally different ALK variants. Amongst 71 instances included on this examine, FISH was evaluable in 58 instances. The concordance of ALK IHC with FISH was 75.9% and that with NGS was 84.5%. The sensitivities of FISH and NGS have been 75.6% and 87.5%, respectively. The median progression-free survival of ALK IHC-positive and FISH-negative group was 5.5 months and that of each constructive was 9.97 months. Regardless of intensive analysis and an extended historical past of glucocorticoids being utilized in varied medical areas, they nonetheless generate a problem for customized medication by inflicting resistance or dependence in practically 50% of sufferers handled.
The target of the current examine was to find out the genetic predictors of variable reactions in inflammatory bowel illness sufferers to glucocorticoid remedy. Evaluation of all of the focused DNA sequences for the entire affected person group indicated 121 totally different useful variants. After affiliation analyses of 31 chosen variants, the polymorphism c.1088A>G within the NR3C1 gene was linked with glucocorticoid resistance (p = 0.002), variant c.241+6A>G of the FKBP5 gene with glucocorticoid sensitivity (p = 0.040), and deletion c.306-7delT within the MAPK14 gene with an hostile therapeutic impact (dependency and resistance, p = 0.041) in ulcerative colitis sufferers.

Affiliation of Postoperative Biomarker Response with Recurrence and Survival in Sufferers with Hepatocellular Carcinoma and Excessive Alpha-Fetoprotein Expressions (>400 ng/ml)

Excessive alpha-fetoprotein (AFP) expressions (>400 ng/mL) are related to poor oncological traits for hepatocellular carcinoma (HCC). Nevertheless, prognosis after liver resection for high-AFP HCC is poorly studied. To research long-term recurrence and survival after hepatectomy for high-AFP HCC, and to establish the predictive worth of postoperative incomplete biomarker response (IBR) on general survival (OS) and recurrence-free survival (RFS). In Crohn’s illness, the change c.2685+49T>C of the ABCB1 gene associated to glucocorticoid resistance (p = 0.034).
Sufferers present process healing resection for high-AFP HCC have been analyzed. In line with the decline magnitude of serum AFP as measured at first follow-up (4~6 weeks after surgical procedure), all sufferers have been divided into the whole biomarker response (CBR) and IBR teams. Traits, recurrence, and survival charges have been in contrast. Univariate and Multivariate Cox-regression analyses have been carried out to establish impartial predictors related to poorer OS and RFS after liver resection for high-AFP HCC.
Amongst 549 sufferers, the general and early recurrence charges in sufferers with IBR have been considerably larger than sufferers with CBR. On multivariate evaluation, postoperative IBR was the strongest danger issue with the best hazard ratio in predicting poor OS and RFS.
Postoperative biomarker response of serum AFP can be utilized in predicting recurrence and survival for high-AFP HCC sufferers. As soon as postoperative IBR was recognized at first follow-up, subsequent enhanced recurrence surveillance and accessible remedies towards recurrence ought to actively be thought of. Holocene have been reconstructed. The research on intraspecific gene stream and homoploid hybridization targeted on hybrid swarms Pinus sylvestris/P. mugo and firs.
IHC versus FISH versus NGS to detect ALK gene rearrangement in NSCLC: all questions answered?

18F-fluciclovine PET/CT detection of biochemical recurrent prostate most cancers in sufferers with PSA ranges <2.00 ng/mL

To ascertain the detection price of prostate most cancers recurrence following definitive remedy by 18F-fluciclovine PET/computed tomography (CT) in sufferers with biochemical recurrence (BCR) and prostate-specific antigen (PSA) ranges lower than 2.00 ng/mL. On this retrospective examine, 78 sufferers with a PSA degree of lower than 2.00 ng/mL have been chosen from the 211 sufferers who underwent no less than one 18F-fluciclovine PET/CT scan at our establishment for the detection of biochemical recurrent prostate most cancers between April 2017 and December 2018. Inherent variations within the traits of sufferers with and with out a constructive scan have been investigated for potential associations utilizing multivariable evaluation.
A number of constructive websites of recurrence have been recognized in 44 out of 78 sufferers (56.4%). Sufferers with a Gleason rating between eight and 10 have been extra prone to have a constructive scan in comparison with sufferers with Gleason scores of 6-7 [adjusted odds ratio: 3.53, 95% confidence interval (1.13-10.99), P = 0.03]. No different vital affiliation was discovered between PSA, T classification, and detection price. 18F-fluciclovine PET/CT demonstrated a detection price of 56.4% amongst sufferers with a PSA under 2.Zero ng/mL. The outcomes of this examine assist the usage of 18F-fluciclovine PET/CT for the detection of recurrent prostate most cancers at decrease PSA ranges, even at PSA ranges lower than 0.5 ng/mL

WUV-M20, UV Transilluminator, 312nm, 100V

3532197 1unit
EUR 1149.72

WUV-M20, UV Transilluminator, 312nm, 220V

3532198 1unit
EUR 1149.72

UltraBright UV Transilluminator, 302/365 nm

Q-MLB-16 1
EUR 1050

Accuris™ UV Transilluminator, 230V input

E3000-E 1 PC
EUR 1255.7

Accuris™ UV Transilluminator, 230V input

BM0299 Ea
EUR 1567.2

UV Transilluminator 20 x 20 cm 302nm - EACH

ELE7584 EACH
EUR 1274.4

UV Transilluminator 25 x 30 cm 302nm - EACH

ELE7586 EACH
EUR 1742.85

Accuris MyView Compact UV Transilluminator 230V

ELE1261 EACH
EUR 875.52

UV Transilluminator 21 x 21cm 254nm - EACH

ULT4500 EACH
EUR 1455.3

UV Transilluminator 21 x 21cm 312nm - EACH

ULT4502 EACH
EUR 1386.45

UV Transilluminator 21 x 21cm 365nm - EACH

ULT4504 EACH
EUR 1386.45

UV Transilluminator 21 x 26cm 254nm - EACH

ULT4510 EACH
EUR 1899.16

UV Transilluminator 21 x 26cm 312nm - EACH

ULT4512 EACH
EUR 1899.16

UV Transilluminator 21 x 26cm 365nm - EACH

ULT4514 EACH
EUR 1899.16

UltraBright UV Transilluminator, 302 nm (Large View)

QMB-21 1
EUR 1150

Accuris MyView™ Compact UV Transilluminator, 230V

E3100-E 1 each
EUR 796.52

Accuris MyView™ Compact UV Transilluminator

E3100 1 each
EUR 796.52

UltraBright UV Transilluminator, 302/365 nm (Large View)

Q-MLB-21 1
EUR 1150

uv transilluminator 20x20cm, 312nm, 50/100% switch

UVTR2200 ea
EUR 1393.2

Mini-Imager Dual UV/LED Transilluminator, 302 nm/470 nm

Q-MI-01 1
EUR 4650

Transilluminator 365nm - EACH

ELE0032 EACH
EUR 1205.88

Transilluminator 302nm - EACH

ELE0034 EACH
EUR 1043.55

Transilluminator 254nm - EACH

ELE0036 EACH
EUR 1205.88

Transilluminator 302nm - EACH

ELE0052 EACH
EUR 1431

UV Transilluminator 21 x 21cm Dual Wave 254/365nm - EACH

ULT4506 EACH
EUR 1452.6

UV Transilluminator 21 x 21cm Dual Wave 254/312nm - EACH

ULT4508 EACH
EUR 1452.6

UV Transilluminator 21 x 26cm Dual Wave 254/365nm - EACH

ULT4516 EACH
EUR 1971.13

Transilluminator 230v 50Hz MW - EACH

ULT4102 EACH
EUR 1066.5

SmartBlue™ Transilluminator

E4000 1 each
EUR 665.24

Blue Light Transilluminator - EACH

ELE3416 EACH
EUR 868.05

EZ-Viewer LED Transilluminator

LED001 set
EUR 624

UltraBright LED Transilluminator, 470 nm

QLB-16 1
EUR 1050

SmartBlue™ Transilluminator, 230V input

E4000-E 1 PC
EUR 665.24

SmartBlue™ Mini Transilluminator

E4100 1 each
EUR 491.64

transilluminator led 20x12 cm + hood

BLOOK ea
EUR 696

microDOC System with UV Transilluminator UVTS365 21x21cm 365nm - EACH

MOL3506 EACH
EUR 6189.75

Transilluminator 20x20cm 302/365 - EACH

ELE2104 EACH
EUR 1421.55

Transilluminator 25x30cm 302/365 - EACH

ELE2106 EACH
EUR 2018.25

Accuris SmartBlue Transilluminator 230V - EACH

ELE1262 EACH
EUR 967.95

SmartBlue™ Mini Transilluminator, 230V input

E4100-E 1 each
EUR 491.64

SmartDoc band pass filter, 590nm, for imaging EtBr on UV transilluminator

E5001-590 1 PC
EUR 137.39

BluePad - Blue/White LED Transilluminator

Bp001CU 1 pcs
EUR 779

Transilluminator Tube for ULT40020622 - EACH

ULT4042 EACH
EUR 37.8

Ultra Bright Blue LED Transilluminator - EACH

ELE7526 EACH
EUR 1252.8

SmartDoc band pass filter, 535nm, for imaging Green Stains on UV transilluminator

E5001-535 1 PC
EUR 137.39

UVPAD, LED Transilluminator, with mini Darkroom

UP001CU Set
EUR 900

SmartDoc band UV Blocking Filter, optimized for use with E3100 transilluminator

E5001-UVBLOCK 1 each
EUR 55.59

BluPAD, LED Transilluminator, with mini Darkroom

BP001CU Set
EUR 350

Orange filter cover for mini LED transilluminator

E1200-OC 1 each
EUR 40.1

Dual LED Transilluminator Gel Documentation System

abx795001-10nmol 10 nmol Ask for price

Dual LED Transilluminator Gel Documentation System

abx795001-5nmol 5 nmol
EUR 962.5

Hi-UV Intense

LA1068-1NO 1 unit
EUR 1500.46
Description: Hi-UV Intense

Hi-UV Duo

LA1069-1NO 1 unit
EUR 1500.46
Description: Hi-UV Duo

Hi-UV Max Capture

LA1067A-1NO 1 unit
EUR 66.7
Description: Hi-UV Max Capture

Hi-UV Intense Capture

LA1068A-1NO 1 unit
EUR 83.35
Description: Hi-UV Intense Capture

Hi-UV Duo Capture

LA1069A-1NO 1 unit
EUR 83.35
Description: Hi-UV Duo Capture

UV TRANSMITTING TRAY

GD-GCS 1/pk
EUR 249.6
Description: Lab Equipment; Axygen Branded EQ

LED Transiluminator - 470nm - EACH

ELE3414 EACH
EUR 496.8

Optional extra shelf, UV Transparent

B1450-SH-UV 1 each
EUR 170.05

Hi-MMLV Reverse Transcriptase

MBT072-1000U 1 unit
EUR 19.28
Description: Hi-MMLV Reverse Transcriptase

Hi-MMLV Reverse Transcriptase

MBT072-5000U 1 unit
EUR 85.89
Description: Hi-MMLV Reverse Transcriptase

Greiner 96 well microplate UV transparent - PK40

G655801 PK40
EUR 326.7

UV Transparent Cutting Platform 22 x 22cm - EACH

ULT4528 EACH
EUR 108

UV Transparent Cutting Platform 22 x 26cm - EACH

ULT4530 EACH
EUR 132.3

UV LAMP FOR ELIX UV - EACH

ZLXUVLP01 EACH
EUR 423.01

UV-0155041

530465 100.0mg
EUR 850

UV-2237M

ABC-TC1269 1 vial Ask for price
Description: Tumorigenecity: Isoenzyme: Histopathology: fibrosarcoma; MDR cellSubculture: Split ratio: Media change: Reverse transcritase: Production.

UV-320

U850210 25g
EUR 81
Description: 3846-71-7

UV-Clave UV-C Indicator Card - PK25

STE1456 PK25
EUR 160.65

UV-Clave UV-C Indicator Stickers - PK40

STE1458 PK40
EUR 141.75

Simplicity½ UV - EACH

SIMSV0001 EACH
EUR 5698.94

Synergy½ UV - EACH

SYNSVHF00 EACH
EUR 7962.36

UV Lamp - EACH

WAT2442 EACH
EUR 680.05

uv protected glasses

VLLP70 ea
EUR 118.8

Multisub Maxi UV Tray - EACH

MS20UV25 EACH
EUR 182.25

BRANDplates pureGrade 96-well PS foil bot UV transp 350ul n-ster - PK50

F781614 PK50
EUR 1050.3

BRANDplates pureGrade 96-well PS foil bot UV transp black n-ster - PK50

F781615 PK50
EUR 1155.6

nUVaClean™ UV Pipette Carousel, with germicidal UV lamp, 115V

P5590 1/pack
EUR 390.88
Description: nUVaClean UV pipette carousel with UV lamp

HI-236

T25501-10mg 10mg Ask for price
Description: HI-236

HI-236

T25501-1g 1g Ask for price
Description: HI-236

HI-236

T25501-1mg 1mg Ask for price
Description: HI-236

HI-236

T25501-50mg 50mg Ask for price
Description: HI-236

HI-236

T25501-5mg 5mg Ask for price
Description: HI-236

HI-207

T27542-10mg 10mg Ask for price
Description: HI-207

HI-207

T27542-1g 1g Ask for price
Description: HI-207

HI-207

T27542-1mg 1mg Ask for price
Description: HI-207

HI-207

T27542-50mg 50mg Ask for price
Description: HI-207

HI-207

T27542-5mg 5mg Ask for price
Description: HI-207

HI Powder

RM191-500G 1 unit
EUR 47.33
Description: HI Powder

HI Agar

M169-100G 1 unit
EUR 15.93
Description: HI Agar

HI Agar

M169-500G 1 unit
EUR 44.34
Description: HI Agar

HI Broth

M170-100G 1 unit
EUR 15.93
Description: HI Broth

HI Broth

M170-500G 1 unit
EUR 44.34
Description: HI Broth

Hi-Incubac

LA862-1NO 1 unit
EUR 335.89
Description: Hi-Incubac

HI Certified

CR032-500G 1 unit
EUR 82.4
Description: HI Certified

SmartDoc UV Blocking Mat

E5000-MAT 1 PC
EUR 47.63

UV Filter (UV032) - EACH

ELE0038 EACH
EUR 625.05

UV LAMP KIT - EACH

CFMQ18501 EACH
EUR 822.53

Replacement UV Tubes - EACH

CAB3084 EACH
EUR 67.5

Azido-C3-UV-biotin

T17475-10mg 10mg Ask for price
Description: Azido-C3-UV-biotin

Azido-C3-UV-biotin

T17475-1g 1g Ask for price
Description: Azido-C3-UV-biotin

Azido-C3-UV-biotin

T17475-1mg 1mg Ask for price
Description: Azido-C3-UV-biotin

Azido-C3-UV-biotin

T17475-50mg 50mg Ask for price
Description: Azido-C3-UV-biotin

Azido-C3-UV-biotin

T17475-5mg 5mg Ask for price
Description: Azido-C3-UV-biotin

Face Shield UV - EACH

SAF1210 EACH
EUR 464.14

UV LAMP SIMPLICITY - EACH

SIM0000UV EACH
EUR 796.09

Synergy½ UV Remote - EACH

SYNSVR000 EACH
EUR 9514.89

A10 UV LAMP - EACH

ZFA10UVM1SIG EACH
EUR 1066.35

Internal UV lamp - EACH

WAT2426 EACH
EUR 768.18

Elga UV Lamp - EACH

WAT4100 EACH
EUR 199.76

uv lamp 1x15w, 254nm

VL115-C ea
EUR 787.2

uv lamp 1x15w, 365nm

VL115-L ea
EUR 787.2

uv lamp 1x15w, 312nm

VL115-M ea
EUR 787.2

uv lamp 2x15w, 254nm

VL215-C ea
EUR 950.4

uv lamp 2x15w, 365nm

VL215-L ea
EUR 950.4

uv lamp 2x15w, 312nm

VL215-M ea
EUR 980.4

uv lamp 1x6w, 254nm

VL6-C ea
EUR 625.2

uv lamp 1x6w, 365nm

VL6-L ea
EUR 625.2

conversion screen uv/blue

VLFC26-BLUE ea
EUR 727.2

conversion screen uv/wl

VLFC26-WL ea
EUR 727.2

uv protected face shield

VLMP80 ea
EUR 219.6

uv protected face shield

VLMP800 ea
EUR 240

UV Viewing Cabinet - EACH

ULT4018 EACH
EUR 862.19

UV Tube for ULT402226

ULT4054 EACH
EUR 31.35

Probe For Hi-9812/Hi-9813 - EACH

HI-1285 EACH
EUR 210.6

AXYGEN® GEL TRAY 10 X 10 CM FOR USE WITH 10 CM GEL BOX, UV TRANSPARENT

HGB10-10-GT 1/pk
EUR 88.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 15 X 10 CM FOR USE WITH 15 CM GEL BOX, UV TRANSPARENT

HGB15-10-GT 1/pk
EUR 94.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 15 X 15 CM FOR USE WITH 15 CM GEL BOX, UV TRANSPARENT

HGB15-15-GT 1/pk
EUR 94.8
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 20 X 20 CM FOR USE WITH 20 CM GEL BOX, UV TRANSPARENT

HGB20-20-GT 1/pk
EUR 116.4
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 7 X 10 CM FOR USE WITH 7 CM GEL BOX, UV TRANSPARENT

HGB7-10-GT 1/pk
EUR 81.6
Description: Lab Equipment; Axygen Branded EQ

AXYGEN® GEL TRAY 7 X 7 CM FOR USE WITH 7 CM GEL BOX, UV TRANSPARENT

HGB7-7-GT 1/pk
EUR 73.2
Description: Lab Equipment; Axygen Branded EQ

Multi Sub Midi UV Tray Dams - EACH

MS10UVDAM EACH
EUR 91.8

Multi Sub Maxi UV Tray Dams - EACH

MS20UVDAM EACH
EUR 97.2

Multi Sub Mini UV Tray Dams - EACH

MS7UVDAM EACH
EUR 71.55

Multi Sub Choice UV Tray Dams - EACH

MS15UVDAM EACH
EUR 91.8

Propellers for HI-931 and HI-932 - PK3

TIT1026 PK3
EUR 36.45

HI-TOPK-032

407118 5.0mg
EUR 240

OPG, Hi-5

cyt-633 2µg
EUR 60
Description: Recombinant Human Osteoprotegerin, Hi-5

1,2-Dimethylisothiourea-HI

D474400 100mg
EUR 75
Description: 41306-45-0

Formamide Hi-Di

44040000-1 100 mL Ask for price

Formamide Hi-Di

44040000-2 500 mL Ask for price

HI TOPK 032

B5640-10 10 mg
EUR 158
Description: T-LAK-cell-originated protein kinase (TOPK) inhibitor

HI TOPK 032

B5640-100 100mg
EUR 920
Description: T-LAK-cell-originated protein kinase (TOPK) inhibitor

HI TOPK 032

B5640-25 25mg
EUR 318
Description: T-LAK-cell-originated protein kinase (TOPK) inhibitor

HI TOPK 032

B5640-5 5 mg
EUR 100
Description: T-LAK-cell-originated protein kinase (TOPK) inhibitor

HI TOPK 032

B5640-50 50mg
EUR 542
Description: T-LAK-cell-originated protein kinase (TOPK) inhibitor

HI-TOPK-032

T15481-10mg 10mg Ask for price
Description: HI-TOPK-032

HI-TOPK-032

T15481-1g 1g Ask for price
Description: HI-TOPK-032

HI-TOPK-032

T15481-1mg 1mg Ask for price
Description: HI-TOPK-032

HI-TOPK-032

T15481-50mg 50mg Ask for price
Description: HI-TOPK-032

HI-TOPK-032

T15481-5mg 5mg Ask for price
Description: HI-TOPK-032

HI-TOPK-032

HY-101550 100mg
EUR 1018.8

HSPA5 Hi-5

hsp-037 5µg
EUR 60
Description: Recombinant Human Heat Shock 70kDa protein 5, Hi-5

HI-THAL KIT

MBP010-50TST 1 unit
EUR 15.32
Description: HI-THAL KIT

Hi-PCR Kit

MBT075-10R 1 unit
EUR 33.82
Description: Hi-PCR Kit

Hi-PCR Kit

MBT075-25R 1 unit
EUR 57.61
Description: Hi-PCR Kit

Hi-FlexiLoop 2

PW012S-1X100NO 1 unit
EUR 8.08
Description: Hi-FlexiLoop 2

Hi-FlexiLoop 2

PW012S-5X100NO 1 unit
EUR 36.31
Description: Hi-FlexiLoop 2

Hi-FlexiLoop 4

PW013S-1X100NO 1 unit
EUR 8.33
Description: Hi-FlexiLoop 4

Hi-FlexiLoop 4

PW013S-5X100NO 1 unit
EUR 36.31
Description: Hi-FlexiLoop 4

Hi-FlexiLoop-S

PW014S-1X100NO 1 unit
EUR 8.08
Description: Hi-FlexiLoop-S

Hi-FlexiLoop-S

PW014S-5X100NO 1 unit
EUR 36.31
Description: Hi-FlexiLoop-S
This overview summarizes the event of inhabitants genetics and inhabitants genomics research of forest bushes in Slovakia in the course of the previous 40 years. Varied protein and DNA markers have been utilized throughout this era to handle a number of subjects in evolutionary genetics and biogeography of bushes: allozymes, uniparentally inherited chloroplast and mitochondrial markers, easy sequence repeats and single nucleotide polymorphisms. The primary object of research of phylogeny and postglacial migration have been Fagus sylvatica s.l. and eastern-Mediterranean firs (Abies Mill. part Abies), the place the divergence of genetic lineages (species and subspecific taxa) in time, in addition to colonization of the present ranges in the course of the

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