Neisseria meningitidis can cause sporadic cases and outbreaks of invasive disease, including meningitis and sepsis. The meningococcal serogroup C (MenC) is the second most common serogroup in Italy after MenB. In this study we have estimated the reproductive numbers and the demographic reconstruction on the genomes of invasive N. meningitidis C:P1.5-1,10-8:F3-6:ST-11(cc11) strains isolated in Italy in 2012-2017, a period that includes the outbreak in Tuscany.

METHODS

The genomes of N. meningitidis were sequenced using the Illumina MiSeq platform, through the whole genome sequencing (WGS) method and were analyzed by the core genome MLST (cgMLST) approach, using the BIGSdb Genome Comparator tool implemented on the PubMLST website. A Bayesian method was applied to study population dynamics across the entire N. meningitidis dataset. The basic reproduction number R0, which indicates the average number of secondary cases generated by a single primary case, was calculated using a Bayesian method, on the dataset and on the two subsets. The effective reproduction number R(t), defined as the average number of secondary cases per infectious case in a population, made up of susceptible and non-susceptible hosts was studied on the Tuscany dataset, with a Bayesian method.

50 bp DNA Ladder
DL008S each
EUR 2.2

50 bp DNA Ladder
M-213L 5 x 500µl
EUR 218.03
Description: ready-to-use, orange

50 bp DNA Ladder
M-213S 500µl
EUR 54.51
Description: ready-to-use, orange

50 bp DNA Ladder
MBS433533-005mg 0.05mg
EUR 215

50 bp DNA Ladder
MBS433533-5x005mg 5x0.05mg
EUR 815

50 bp DNA Marker
BS97.700.0500 500 μL Ask for price
Description: 50 bp DNA Marker - ohne Ladepuffer14 Banden: 50 bp bis 1.000 bpExakte SizenbestimmungRelative QuantifizierungAlle Fragmente haben glatte Enden "blunt ends"Verstärkte 250 und 500 bp Banden (Referenzbanden) 50 bp DNA Marker:Das Produkt wird ohne Ladepuffer verkauft. Zum Beladen des Geles ist aber noch ein Ladepuffer nötig. Wir bieten dafür Ladepuffer mit dem Farbstoff Bromphenolblau (Artikel-Nr.:BS85.112.005) oder Orange G (Artikel-Nr.:BS85.111.010) an.Anwendung:Verwenden Sie 5 µl des DNA Markers pro Geltasche.Hinweis:Wir haben die Einheiten unserer DNA Marker geändert. Die 500 µl-Gebindegröße des aktuellen DNA Markers enstpricht der 50 µg-Gebindegröße unseres alten Produkts. Die 5x 500 µl Gebindegröße des aktuellen DNA Markers entspricht der 250 µg-Gebindegröße unseres alten Produkts.

HE 3286
MBS5778676-5mg 5(mg
EUR 915

HE 3286
MBS5778676-5x5mg 5x5(mg
EUR 3970

HE 3286
T29013-10mg 10mg Ask for price
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GScan Marker Tamra Labeled 50 bp - 600 bp
40-3061-01 100 µL Ask for price

GScan Marker Tamra Labeled 50 bp - 600 bp
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GScan Marker Hex Labeled 50 bp - 600 bp
40-3081-01 100 µL Ask for price

GScan Marker Hex Labeled 50 bp - 600 bp
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Geliteâ„¢ 50 bp DNA Ladder
17750 0.5mL
EUR 97
Description: The Geliteâ„¢ 50 bp DNA Ladder is ideal for sizing and approximating the mass of double-stranded DNA within the 50 to 1,500 bp range on agarose or polyacrylamide gels.

50 bp Ladder DNA Marker
FYD004-500UL 32.5 µg/ 500 µl Ask for price

Fluorescent 50 bp DNA Ladder
M-233L 5 x 500µl
EUR 261.58
Description: ready-to-use, orange, green fluorescent

Fluorescent 50 bp DNA Ladder
M-233S 500µl
EUR 65.47
Description: ready-to-use, orange, green fluorescent

Prestained DNA Marker (50-500 bp)
MKD1001-250mL 250μL
EUR 22.8

Accurate DNA Marker (50-500 bp)
MKD3001-250mL 250μL
EUR 18

Accurate DNA Marker (50-1000 bp)
MKD3002-250mL 250μL
EUR 21.6

Omni-Marker™ GScan-2 Tamra labeled 50 bp- 600 bp
40-3062-01 100 µL Ask for price

Omni-Marker™ GScan-2 Tamra labeled 50 bp- 600 bp
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Perfect PlusTM 50-500 bp DNA Ladder
E3145-01 100loadings
EUR 66.49
Description: Ready to Use ladder for sizing small DNA fragments from 50 to 500 bp(50, 100, 250, 400, 500 bp)

Perfect PlusTM 50-500 bp DNA Ladder
E3145-02 500loadings
EUR 263.78
Description: Ready to Use ladder for sizing small DNA fragments from 50 to 500 bp(50, 100, 250, 400, 500 bp)

50 bp DNA Marker - mit separatem Ladepuffer
BS97.701.0500 500 μL Ask for price
Description: 50 bp DNA Marker - mit separatem Ladepuffer14 Banden: 50 bp bis 1.000 bpExakte SizenbestimmungRelative QuantifizierungAlle Fragmente haben glatte Enden "blunt ends"Verstärkte 250 bp und 500 bp Banden (Referenzbanden) 50 bp DNA Marker - mit separatem Ladepuffer:Im Lieferumfang ist 10-fach konzentrierter Ladepuffer (mit Bromphenolblau-Farbstoff) enthalten. Für ein optimales Ergebnis empfehlen wir die zu analysierenden Proben ebenfalls mit dem Ladepuffer zu mischen.Anwendung:Verwenden Sie 5 µl des DNA Markers pro Geltasche.Hinweis:Wir haben die Einheiten unserer DNA Marker geändert. Die 500 µl-Gebindegröße des aktuellen DNA Markers enstpricht der 50 µg-Gebindegröße unseres alten Produkts. Die 5x 500 µl Gebindegröße des aktuellen DNA Markers entspricht der 250 µg-Gebindegröße unseres alten Produkts.

50 bp DNA Marker - "ready-to-load"
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BP
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Cellulose, microcrystalline powder, 50 micron, BP, Ph. Eur., USP grade
GV9004 250g
EUR 130.36

Cellulose, microcrystalline powder, 50 micron, BP, Ph. Eur., USP grade
GV9004-1 1
EUR 142.4

Cellulose, microcrystalline powder, 50 micron, BP, Ph. Eur., USP grade
GV9004-1KG 1 kg
EUR 208.8

Cellulose, microcrystalline powder, 50 micron, BP, Ph. Eur., USP grade
GV9004-250 250
EUR 51.4

Cellulose, microcrystalline powder, 50 micron, BP, Ph. Eur., USP grade
GV9004-250G 250 g
EUR 98.4

Glycine BP
74072 1 Kg
EUR 8.21
Description: Part A

Proline BP
61988 1 Kg
EUR 54.74
Description: Part A

BP 294
B676700 25mg
EUR 75
Description: 139191-80-3

BP 897
HY-114085 Get quote Ask for price
Description: BP 897 is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM)[1].

BP-1
pro-463 2µg
EUR 175
Description: Recombinant Human BP-1

BP 897
T9100-10mg 10mg Ask for price
Description: BP 897

BP 897
T9100-1g 1g Ask for price
Description: BP 897

BP 897
T9100-1mg 1mg Ask for price
Description: BP 897

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T9100-50mg 50mg Ask for price
Description: BP 897

BP 897
T9100-5mg 5mg Ask for price
Description: BP 897

BP 294
TRC-B676700-25MG 25 mg Ask for price

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TRC-B676700-50MG 50 mg Ask for price

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TRC-B676700-5MG 5 mg Ask for price

100 bp DNA Ladder (100 bp ~ 1,500 bp, with loading dye)
W0636-100 100 rxn
EUR 199

Universal DNA Marker (100 bp ~ 10,000 bp)
W2583-100 100 rxn
EUR 129

Universal DNA Marker (100 bp ~ 10,000 bp)
W2583-50 50 rxn
EUR 59

Universal DNA Marker (100 bp ~ 10,000 bp)
W2583-500 500 rxn
EUR 399

Subcloing bundled with gene synthesis3001 bp ~ 5000 bp
GC0012 3001 bp ~ 5000 bp
EUR 39

Nucleophosmin (Acute Myeloid Leukemia Marker)(NPM1/3286), 1mg/mL
BNUM3286-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nucleophosmin (Acute Myeloid Leukemia Marker)(NPM1/3286), 0.2mg/mL
BNUB3286-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Nucleophosmin (Acute Myeloid Leukemia Marker)(NPM1/3286), 0.2mg/mL
BNUB3286-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CREB-BP Antibody
8C0161 50ug
EUR 368
Description: CREB-BP Antibody

CREB-BP Antibody
33346 100ul
EUR 319

CREB-BP Antibody
33346-100ul 100ul
EUR 302.4

CREB-BP Antibody
33346-50ul 50ul
EUR 224.4

Ran BP antibody
22886 100ul
EUR 479

BP-1-102
406523 5.0mg
EUR 85

CREB- BP Antibody
ABF0139 100 ug
EUR 525.6

PPAR- BP Antibody
ABF6446 100 ug
EUR 525.6

Propyl Gallate BP
14086 1 Kg
EUR 54.74
Description: Part A

epsilon BP Antibody
abx018318-100ug 100 ug
EUR 460.8

epsilon BP Antibody
abx018318-200g 200 µg
EUR 300

BP-1-108
B676705 250mg
EUR 12800
Description: 1334492-85-1

BP 554 Maleate
B676723 500mg
EUR 4500
Description: 1221401-95-1

BP 554 maleate
B6351-10 10 mg
EUR 183.2
Description: Neuroscience|5-HT Receptor

BP 554 maleate
B6351-50 50 mg
EUR 773.6
Description: Neuroscience|5-HT Receptor

BP-73 Antibody
CSB-PA814457XA01OFG-02mg 0.2mg Ask for price
Description: Recombinant Oryza sativa subsp. japonica (Rice) BP-73 protein

BP-73 Antibody
CSB-PA814457XA01OFG-10mg 10mg Ask for price
Description: Recombinant Oryza sativa subsp. japonica (Rice) BP-73 protein

BP-1 Protein
20-abx263543
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  • 2 µg
  • 5 ug
  • 10 ug

CREB-BP Antibody
AF0861 200ul
EUR 420

CREB-BP Antibody
AF0861-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

CREB-BP Antibody
AF0861-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

CREB-BP Antibody
AF0139 200ul
EUR 420

CREB-BP Antibody
AF0139-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

CREB-BP Antibody
AF0139-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

AI-BP Antibody
C14522-100ul 100μl
EUR 217
Description: AI-BP Rabbit Polyclonal Antibody

AI-BP Antibody
C14522-50ul 50μl
EUR 143.5
Description: AI-BP Rabbit Polyclonal Antibody

BP-1-102
HY-100493 100mg
EUR 487.02
Description: BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.

BP 897 (hydrochloride)
HY-106660 1 mg
EUR 1893.97
Description: BP 897 hydrochloride is a potent and partial dopamine D3 receptor agonist and a weak D2 receptor antagonist. BP 897 hydrochloride displays a high affinity at the dopamine D3 receptor (Ki=0.92 nM) and a 70 times lower affinity at the D2 receptor (Ki=61 nM)[1].

Naproxen, BP grade
GP6640 25g
EUR 130.36

Naproxen, BP grade
GP6640-25 25
EUR 142.4

Naproxen, BP grade
GP6640-25G 25 g
EUR 208.8

CREB-BP Antibody
E11-0161C 100μg/100μl
EUR 225
Description: Available in various conjugation types.

PPAR-BP Antibody
E18-6446-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

PPAR-BP Antibody
E18-6446-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

CREB-BP Antibody
E033346 100μg/100μl
EUR 255
Description: Available in various conjugation types.

CREB-BP Antibody
E18-0139-1 50μg/50μl
EUR 145
Description: Available in various conjugation types.

CREB-BP Antibody
E18-0139-2 100μg/100μl
EUR 225
Description: Available in various conjugation types.

BP-1-102
MBS3601334-10mg 10mg
EUR 270

BP-1-102
MBS3601334-25mg 25mg
EUR 390

BP-1-102
MBS3601334-2mg 2mg
EUR 210

BP-1-102
MBS3601334-50mg 50mg
EUR 620

BP-1-102
MBS3601334-5mg 5mg
EUR 235

BP-1-102
MBS3844793-10mg 10mg
EUR 285

BP-1-102
MBS3844793-2mg 2mg
EUR 140

BP-1-102
MBS3844793-50mg 50mg
EUR 710

BP-1-102
MBS3844793-5mg 5mg
EUR 185

BP-1-102
MBS3844793-5x50mg 5x50mg
EUR 3195

BP 897 hydrochloride
MBS5765578-10mg 10mg
EUR 540

BP 897 hydrochloride
MBS5765578-1mg 1mg
EUR 235

BP 897 hydrochloride
MBS5765578-25mg 25mg
EUR 940

BP 897 hydrochloride
MBS5765578-50mg 50mg
EUR 1435

BP 897 hydrochloride
MBS5765578-5mg 5mg
EUR 375

MGB-BP-3
MBS5769523-100mg 100mg
EUR 1685

MGB-BP-3
MBS5769523-50mg 50mg
EUR 1075

MGB-BP-3
MBS5769523-5x100mg 5x100mg
EUR 7425

BP-1-102
MBS578568-10mg 10mg
EUR 210

BP-1-102
MBS578568-50mg 50mg
EUR 425

BP-1-102
MBS578568-5mg 5mg
EUR 165

BP-1-102
MBS578568-5x50mg 5x50mg
EUR 1765

PPAR-BP Antibody
MBS9601995-01mL 0.1mL
EUR 260

PPAR-BP Antibody
MBS9601995-02mL 0.2mL
EUR 305

PPAR-BP Antibody
MBS9601995-5x02mL 5x0.2mL
EUR 1220

CREB-BP Antibody
MBS9600077-01mL 0.1mL
EUR 260

CREB-BP Antibody
MBS9600077-02mL 0.2mL
EUR 305

CREB-BP Antibody
MBS9600077-5x02mL 5x0.2mL
EUR 1220

CREB-BP Antibody
MBS8510634-005mg 0.05mg
EUR 235

CREB-BP Antibody
MBS8510634-01mg 0.1mg
EUR 305

CREB-BP Antibody
MBS8510634-01mLAF405M 0.1mL(AF405M)
EUR 465

CREB-BP Antibody
MBS8510634-01mLAF546 0.1mL(AF546)
EUR 465

CREB-BP Antibody
MBS8510634-01mLAF750 0.1mL(AF750)
EUR 465

CREB-BP Antibody
MBS855363-01mg 0.1mg
EUR 305

CREB-BP Antibody
MBS855363-01mLAF405L 0.1mL(AF405L)
EUR 465

CREB-BP Antibody
MBS855363-01mLAF405S 0.1mL(AF405S)
EUR 465

CREB-BP Antibody
MBS855363-01mLAF610 0.1mL(AF610)
EUR 465

CREB-BP Antibody
MBS855363-01mLAF635 0.1mL(AF635)
EUR 465

PPAR-BP Antibody
MBS8512453-005mg 0.05mg
EUR 235

PPAR-BP Antibody
MBS8512453-01mg 0.1mg
EUR 305

PPAR-BP Antibody
MBS8512453-01mLAF405M 0.1mL(AF405M)
EUR 465

PPAR-BP Antibody
MBS8512453-01mLAF546 0.1mL(AF546)
EUR 465

PPAR-BP Antibody
MBS8512453-01mLAF750 0.1mL(AF750)
EUR 465

CREB-BP Antibody
MBS9403293-005mL 0.05mL
EUR 245

CREB-BP Antibody
MBS9403293-01mL 0.1mL
EUR 305

CREB-BP Antibody
MBS9403293-5x01mL 5x0.1mL
EUR 1230

PPAR-BP Antibody
MBS9503645-005mL 0.05mL
EUR 285

PPAR-BP Antibody
MBS9503645-01mL 0.1mL
EUR 385

PPAR-BP Antibody
MBS9503645-5x01mL 5x0.1mL
EUR 1590

CREB-BP Antibody
MBS9504565-005mL 0.05mL
EUR 285

CREB-BP Antibody
MBS9504565-01mL 0.1mL
EUR 385

CREB-BP Antibody
MBS9504565-5x01mL 5x0.1mL
EUR 1590

BP-1-102
T3708-10mg 10mg Ask for price
Description: BP-1-102

BP-1-102
T3708-1g 1g Ask for price
Description: BP-1-102

BP-1-102
T3708-1mg 1mg Ask for price
Description: BP-1-102

BP-1-102
T3708-50mg 50mg Ask for price
Description: BP-1-102

BP-1-102
T3708-5mg 5mg Ask for price
Description: BP-1-102

dsRNA 142 bp
RNT-SCI-10080100 50µg
EUR 265.36

BP 897 hydrochloride
T14767-10mg 10mg Ask for price
Description: BP 897 hydrochloride

BP 897 hydrochloride
T14767-1g 1g Ask for price
Description: BP 897 hydrochloride

BP 897 hydrochloride
T14767-1mg 1mg Ask for price
Description: BP 897 hydrochloride

BP 897 hydrochloride
T14767-50mg 50mg Ask for price
Description: BP 897 hydrochloride

BP 897 hydrochloride
T14767-5mg 5mg Ask for price
Description: BP 897 hydrochloride

MGB-BP-3
T16071-10mg 10mg Ask for price
Description: MGB-BP-3

MGB-BP-3
T16071-1g 1g Ask for price
Description: MGB-BP-3

MGB-BP-3
T16071-1mg 1mg Ask for price
Description: MGB-BP-3

MGB-BP-3
T16071-50mg 50mg Ask for price
Description: MGB-BP-3

MGB-BP-3
T16071-5mg 5mg Ask for price
Description: MGB-BP-3

BP 554 Maleate
TRC-B676723-500MG 500 mg Ask for price

EasyNAT BP Assay
U20209 test Ask for price

BP-1-108
TRC-B676705-250MG 250 mg Ask for price

100 bp DNA Ladder Plus, ready-to-use, 50 ug, 0.5 ug per lane
Z6030001-1 100 lanes
EUR 45.5

100 bp DNA Ladder Plus, loading dye included, 50 ug, 0.5 ug per lane
Z6030001-2 100 lanes
EUR 40.25

Recombinant Protobothrops flavoviridis Phospholipase A2 isozyme BP-I/BP-II
MBS1016798-005mgBaculovirus 0.05mg(Baculovirus)
EUR 970

Recombinant Protobothrops flavoviridis Phospholipase A2 isozyme BP-I/BP-II
MBS1016798-005mgEColi 0.05mg(E-Coli)
EUR 625

Recombinant Protobothrops flavoviridis Phospholipase A2 isozyme BP-I/BP-II
MBS1016798-005mgYeast 0.05mg(Yeast)
EUR 800

Recombinant Protobothrops flavoviridis Phospholipase A2 isozyme BP-I/BP-II
MBS1016798-02mgEColi 0.2mg(E-Coli)
EUR 805

Recombinant Protobothrops flavoviridis Phospholipase A2 isozyme BP-I/BP-II
MBS1016798-05mgEColi 0.5mg(E-Coli)
EUR 880

Anti-CREB-BP Antibody
A00205 100ul
EUR 360
Description: Boster Bio Anti-CREB-BP Antibody (Catalog # A00205). Tested in WB, IHC, IF applications. This antibody reacts with Human.

IL18 BP Recombinant Protein
96-467 0.2 mg
EUR 588.3
Description: Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.

IL18 BP Recombinant Protein
96-469 0.2 mg
EUR 651.3
Description: Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor. IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain. IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane. IL18BP is strongly expressed in heart, lung, placenta and spleen. Isoform A of IL18BP binds to IL-18 and inhibits its activity. IL18BP also functions as an inhibitor of the early TH1 cytokine response. IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.

BP-PR200Plus AA Systems
360540 Piece of 1 Piece(s)
EUR 1782.27
Description: Description Dutch: BP-PR 200 PLUS; Description French: Imprimante 203 dpi BradyPrinter - 220 V

Ran BP-1 antibody
22886-100ul 100ul
EUR 468

Recombinant Human BP-1
7-04579 2µg Ask for price

Recombinant Human BP-1
7-04580 5µg Ask for price

Recombinant Human BP-1
7-04581 10µg Ask for price

BP-1 Human (Recombinant)
22061154-1 2 µg
EUR 237.47

AI-BP Polyclonal Antibody
ABP50614-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AI-BP from Human, Mouse, Rat. This AI-BP antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AI-BP at AA range: 90-170

AI-BP Polyclonal Antibody
ABP50614-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AI-BP from Human, Mouse, Rat. This AI-BP antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AI-BP at AA range: 90-170

AI-BP Polyclonal Antibody
ABP50614-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AI-BP from Human, Mouse, Rat. This AI-BP antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human AI-BP at AA range: 90-170

AI-BP Polyclonal Antibody
BT-AP00303-100ul 100ul Ask for price
Description: The product (NAD (P)HX epimerase) of NAXE interacts with apolipoprotein A-I (apoA-I), the major apolipoprotein of high-density lipoproteins (HDLs). It is secreted into some bodily fluids, and its synthesis and secretion are stimulated in vitro by incubating cells with apoA-I. The human genome contains related pseudogenes.

RESULTS

An increase in the effective number of the N. meningitidis infections was observed between 2013 and 2016. The estimated R0 parameter was 1.31 (95% HPD: 1.03-1.64), 1.22 (95% HPD: 0.90-1.64) and 1.4 (95% HPD: 0.91-1.9) for the entire dataset, first and second subset, respectively. The BDSKY estimated an initial R(t) of about 2.0 (95% HPD: 0.04-5.0), which showed a growing trend at the end of 2014, reaching an average value of 3.22 in 2015, and then declining below 1 from the year 2016.Monitoring the effective reproduction number can help to inform future vaccination strategies. The increase in the reproductive number for the Tuscany dataset, was consistent with the amplification event that led to the Tuscany outbreak. Subsequently, the intervention that led to the decline of the cases was followed, suggesting a high effectiveness of the vaccination campaign.